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GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47082 | biostudies-arrayexpress
TranscriptomicsYY1 Controls Em-3â??RR DNA Loop Formation and Immunoglobulin Heavy Chain Class Switch Recombination.
Activation of splenic B cells induces formation of a 220kb DNA loop between Em and 3â??RR enhancers in the immunoglobulin heavy chain locus (IgH). This DNA loop has been proposed to be necessary for the crucial immune diversification mechanism of IgH class switch recombination, but the factors that...
ORGANISM(S): Mus musculus 
2016-08-06 | E-GEOD-85259 | biostudies-arrayexpress
UnknownmRNA display-enabled discovery of proximity-triggered covalent peptide-drug conjugates.
Not available
S-EPMC12541606 | biostudies-literature
TranscriptomicsRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Transcriptional profiling was done following APE1/Ref1 silencing using conditional gene expression knockdown by RNA interference (RNAi) technology in HeLa cell lines. APE1 is a DNA-repair enzyme and transcriptional co-activator. Knockdown leads to cell-growth arrest, apoptosis and impairment in the ...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-MEXP-1315 | biostudies-arrayexpress
TranscriptomicsHemangioblast skewing from embryonic stem(ES) cells by defined factors
Successful derivation of a specific cell lineage from pluripotent stem cells will tremendously facilitate the clinical usage of pluripotent stem derived somatic cells. Herein, we demonstrate that ER71/Etv2, GATA2 and Scl form a core network in hemangioblast development and that transient co-expressi...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-45147 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47085 | biostudies-arrayexpress
ProteomicsChinese yew seed dormancy and germination
This project try to provide Chinese yew dormant and germinating seed proteome
ORGANISM(S): Taxus Mairei 
2023-06-02 | PXD042641 |
TranscriptomicsComprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factorl
MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-71204 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of fluorescence-activated sorted Mesp-GFP-labeled B7.5 founder trunk ventral cell lineage cells from Ciona intestinalis
The Ciona heart progenitor lineage (TVC, trunk ventral cells) is first specified by Fibroblast Growth Factor/Map Kinase (FGF/MapK) activation of the transcription factor Ets1/2 (Ets). For this analysis, B7.5 lineage cells were labeled with the Mesp-GFP reporter. In the first experiment, we targeted ...
ORGANISM(S): Ciona intestinalis 
2012-06-04 | E-GEOD-38313 | biostudies-arrayexpress
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