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We tested the hypothesis that the B. fragilis T6SS effector-toxin Bte3 forms a pre-secretion complex with its specific VgrG and the proposed accessory proteins encoded by orf2 and orf3. To test this, we generated functional pEV1/bte1_3(orf2/3) derivatives on the N1 t6-1 t6-2 background in which we H...
ORGANISM(S): Bacteroides fragilis JCM 11017 
2026-05-05 | PXD077331 | Pride
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
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