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TranscriptomicsThe stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6
The budding yeast transcriptional corepressor Tup1-Ssn6 is a model for studying similar repressosome complexes in multicellular eukaryotes. Tup1-Ssn6 does not bind DNA directly, but is directed to individual promoters by one or more DNA-binding proteins, referred to as Tup1 recruiters. We determined...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-01 | E-GEOD-26311 | biostudies-arrayexpress
UnknownCellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.
Not available
S-EPMC5806534 | biostudies-literature
TranscriptomicsGene profiling of TRA1 and tra1-L3733A
Tra1 is a component of the Saccharomyces cerevisiae SAGA and NuA4 complexes and a member of the phosphatidylinositol 3-kinase kinase family that contain a C-terminal PI3K domain followed by a 35-residue FATC domain. We analyzed alleles with single residue changes in the FATC domain. Of these tra1-L3...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-19 | E-GEOD-18591 | biostudies-arrayexpress
TranscriptomicsTranscriptional Control by the FATC Domain of Saccharomyces cerevisiae Tra1
Tra1 is a component of the Saccharomyces cerevisiae SAGA and NuA4 complexes and a member of the phosphatidylinositol 3-kinase (PI3K) related kinase family that contain a C- terminal PI3K domain followed by a ~ 35-residue FATC domain. We have characterized four alleles with single residue changes in ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-30 | E-GEOD-13561 | biostudies-arrayexpress
TranscriptomicsEvaluating Gene Expression in C57BL/6J and DBA/2J Mouse Striatum Using RNA-Seq and Microarray
C57BL/6J (B6) and DBA/2J (D2) are two of the most commonly used inbred mouse strains in neuroscience research. However, the only currently available mouse genome is based entirely on the B6 strain sequence. Subsequently, oligonucleotide microarray probes are based solely on this B6 reference sequenc...
ORGANISM(S): Mus musculus 
2011-04-12 | E-GEOD-26024 | biostudies-arrayexpress
TranscriptomicsHuman Embryoid Body Transcriptomes Reveal Maturation Differences Influenced by Size and Formation in Custom Microarrays
Stem cell differentiation strategies and optimization for generating lineage-specific cells and tissues most frequently rely on a three-dimensional embryoid body (EB) intermediate. We previously applied nanotechnology tools of photolithography to generate custom microarrays that allow high throughpu...
ORGANISM(S): Homo sapiens 
2015-12-05 | E-GEOD-74792 | biostudies-arrayexpress
GenomicsChromatin architectures at fission yeast transcriptional promoters and replication origins
We have used micrococcal nuclease (MNase) digestion followed by deep sequencing in order to obtain a higher-resolution map than previously available of nucleosome positions in the fission yeast, Schizosaccharomyces pombe. Our data confirm an unusually short average nucleosome repeat length, ~152 bp,...
ORGANISM(S): Schizosaccharomyces pombe 
2012-04-23 | E-GEOD-28071 | biostudies-arrayexpress
UnknownCharacterizing Twitter Content About HIV Pre-exposure Prophylaxis (PrEP) for Women: Qualitative Content Analysis.
Not available
S-EPMC10214116 | biostudies-literature
UnknownHPNA 2019-2022 Research Agenda: Development and Rationale.
Not available
S-EPMC6776462 | biostudies-literature
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
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