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TranscriptomicsDirect reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-35653 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between MEFs, MEFs (NWD), immature Sertoli cells and mature Sertoli cells
To compare the the genomic profile of MEFs, immature Sertoli, mature Sertoli cells, and MEFs (NWD) after infection of Nr5a1, Wt1 and Dmrt1 after 1 month of dox exposure. MEFs (NWD) were infected with Nr5a1, Wt1 and Dmrt1 and were exposed to dox for 1 month. MEFs, immature Sertoli and mature Sertoli ...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39649 | biostudies-arrayexpress
TranscriptomicsGene expression comparison between different stages of endogenous Sertoli cells and induced embryonic Sertoli cells derived from MEFs and TTFs
To compare the transcriptional profile of endogenous Sertoli cells from different Stage of Sertoli cell development (embryonic, immature, mature) to the transcriptionla profile of induced embryonic Sertoli cells derived from MEFs or TTFs we employed the agilent whole genome microarray Keywords: Exp...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39648 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between MEFs and induced embryonic Sertoli-like cells
To compare the the genomic profile of MEFs and induced embryonic Sertoli-like cells following 2 weeks of dox withdrawal. ieSCs (from MEFs and from TTFs) and MEF control were grown in F12/DMEM medium without dox for two weeks.
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39650 | biostudies-arrayexpress
GenomicsConversion of Fibroblasts into Functional Trophoblast Stem-like Cells
Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress
GenomicsThe developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors (SNEL iPSC and H2A.X deposition pattern)
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4 and Myc (OSKM) into somatic cells. Though iPSCs are pluripotent, they frequently exhibit high variation in their quality as measured by chimera contribution and tetraploid (4n) complementation. Thus, im...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-55731 | biostudies-arrayexpress
TranscriptomicsReprogramming by Sall4, Nanog, Esrrb and Lin28 produces high quality iPSCs with a molecular signature of developmental potency that resembles ESCs.
To reveal a gene expression signature associated with developmental competence, we selected the following groups of iPSC lines for microarray analysis. i) “Poor quality” iPSCs: This group included the three OSKM-iPSC lines Nanog-GFP OSKM#2, Oct4-GFP OSKM#2 and KH2 OSKM27, that either did not produce...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-45173 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
Analysis of miRNA expression in human breast cancer samples with Agilent's miRNA arrays. These samples are part of a study where we have investigated the mammalian cell proliferation control network consisting of transcription regulators, E2F and p53, their targets, and a family of 14 microRNAs. We ...
ORGANISM(S): Homo sapiens 
2008-09-22 | E-GEOD-12848 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
miRNA expression profiles of WI38 primary human fibroblasts with an active or inactive p53. Cells were compared under normal untreated conditions (young and proliferating cells), after DNA damage with Doxorubicin, and upon entry into replicative senescence. Keywords: miRNA, WI-38, p53, GSE56, Senes...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12450 | biostudies-arrayexpress
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