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TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
TranscriptomicsCancer associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point
Recurrent mutations in the spliceosome are observed in several human cancers but their functional and therapeutic significance remain elusive. SF3B1, the most frequently mutated component of the spliceosome in cancer, is involved in the recognition of the branch point sequence (BPS) during selection...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-72790 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK N1-C+
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27799 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27794 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT, GMP WT and GMP NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27811 | biostudies-arrayexpress
TranscriptomicsSRSF2 mutations impair hematopoiesis and alter exon recognition
Mutations within genes encoding spliceosomal proteins are the most common class of mutations in patients with myelodysplastic syndromes, yet it is currently not well understood how these mutations impact hematopoiesis or RNA splicing. Here we report that mutations affecting the splicing factor SRSF2...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-65349 | biostudies-arrayexpress
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