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ProteomicsBuparlisib-treated Patient Derived Xenograft (PDX) Reversed Phase Protein Array (RPPA) Data
Phosphoinositide 3-kinase (PI3K) signaling activation is frequently observed in triple negative breast cancer, however, PI3K inhibitors have shown limited clinical activity. To investigate resistance mechanisms, we performed global transcriptome, proteome, phosphoproteome and kinome analysis of a pa...
ORGANISM(S): Homo sapiens 
2018-05-29 | GSE100567 | GEO
UnknownResearch update on the anticancer effects of buparlisib.
Not available
S-EPMC7885152 | biostudies-literature
TranscriptomicsAP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [RNA-seq]
Abstract:AP-2α (encoded by TFAP2A) functions as a tumor suppressor and influences response to therapy in several cancer types. We aimed to characterize regulation of the transcriptome by AP-2α in colon cancer. Results: Knockout of TFAP2A induced significant alterations in the transcriptome including...
ORGANISM(S): Homo sapiens 
2021-06-01 | GSE155162 | GEO
GenomicsAP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [ChIP-seq]
Abstract:AP-2α (encoded by TFAP2A) functions as a tumor suppressor and influences response to therapy in several cancer types. We aimed to characterize regulation of the transcriptome by AP-2α in colon cancer. Results: Knockout of TFAP2A induced significant alterations in the transcriptome including...
ORGANISM(S): Homo sapiens 
2021-06-01 | GSE155165 | GEO
ProteomicsIMPRINTS-CETSA Alpelisib and Buparlisib in MCF-7 cells, 6h incubation
IMPRINTS-CETSA data acquisition of MCF-7 cells treated with Vehicle (DMSO), Alpelisib and Buparlisib using TMT 10 plex.
ORGANISM(S): Homo sapiens (Human) 
2024-10-23 | PXD056197 | Pride
Ms-cetsa Apoptosis Protein interaction state 
ProteomicsIMPRINTS-CETSA Alpelisib and Buparlisib in MCF-7 cells, 1h incubation
IMPRINTS-CETSA data acquisition of MCF-7 cells treated with Vehicle (DMSO), Alpelisib and Buparlisib using TMT 10 plex.
ORGANISM(S): Homo sapiens (Human) 
2024-10-23 | PXD056196 | Pride
Ms-cetsa Apoptosis Protein interaction state 
UnknownProfile of buparlisib and its potential in the treatment of breast cancer: evidence to date.
Not available
S-EPMC5796458 | biostudies-literature
UnknownA phase II study of buparlisib in relapsed or refractory thymomas.
Not available
S-EPMC9623263 | biostudies-literature
GenomicsAP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [RNA-seq]
AP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [RNA-seq]
PRJNA648876 | ENA
GenomicsAP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [ChIP-seq]
AP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer [ChIP-seq]
PRJNA648907 | ENA
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