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ProteomicsDiscovery of a novel antifungal compound, ilicicolin K, through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei
In the quest to discover novel antifungal agents and new antifungal production processes, we investigated the biosynthetic gene cluster (BGC) for ilicicolin H in the fungus Trichoderma reesei. While the BGC is silent under standard cultivation conditions, we achieved to activate it by over-expressi...
ORGANISM(S): Trichoderma reesei 
2025-03-13 | PXD055742 | Pride
Multi-omics Fungi Natural products 
ProteomicsBurger_et_al_ilicicolin_metabolomics
In this study, the ilicicolin biosynthetic gene cluster (BGC) in Trichoderma reesei was genetically activated, and a series of gene cluster enzyme deletions were performed. Mycelia were harvested and subjected to polar extraction. The resulting polar extracts were analyzed using an untargeted lipido...
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) 
MSV000095813 | MassIVE
GenomicsGenome-wide maps of chromatin state in HSC, Pro B and mature B cells
We have used a genome-wide ChIP-sequencing approach to define and investigate the dynamics of the cis-regulatory landscape in three developmental stages of the murine hematopoietic system. To this end, we have compared the profiles of H3K4me3, H3K4me1, H3K27ac, H3K27me3 and H3K9me2 in HSCs, committe...
ORGANISM(S): Mus musculus 
2015-10-19 | E-GEOD-60005 | biostudies-arrayexpress
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