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GenomicsThe Genetic Landscape of Mutations in Burkitt Lymphoma

Burkitt lymphoma (BL) is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. We sequenced exomes of 59 BL tumors, 14 of which had paired normal tissue. Our work elucidates commonly occurring gene-coding mutations in Burki...

phs000562.v1.p1 | EGA
TranscriptomicsThe genetic landscape of mutations in Burkitt lymphoma
Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequen...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-48435 | biostudies-arrayexpress
GenomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [RRBS]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-45341 | biostudies-arrayexpress
TranscriptomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [Methylation profiling by array]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-45240 | biostudies-arrayexpress
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