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TranscriptomicsTranscriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression
Acetylcholinesterase (AChE) inhibitors are widely used as pesticides and drugs. Their primary effect is the overstimulation of muscular activity. Whether AChE inhibitors and related neurotoxic compound also provoke specific changes in gene transcription patterns that allow to establish a mechanistic...
ORGANISM(S): Danio rerio 
2011-12-01 | E-GEOD-27680 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos exposed to the model hedgehog pathway inhibitor cyclopamine, as well as to the potential hedghog pathway disrupters SANT-2 and GANT-61.
The hedgehog (Hh) signaling pathway is important for various developmental processes during embryogenesis and for homeostasis of adult tissue in vertebrates. Aberrant signaling results in severe birth defects and malignancies, respectively. The small molecules SANT-2 and GANT-61 were identified as p...
ORGANISM(S): Danio rerio 
2011-09-30 | E-GEOD-29357 | biostudies-arrayexpress
TranscriptomicsMolecular fingerprint of the podocyte reveals novel gene regulatory networks
The thorough characterization of the transcriptome of endogenous podocytes has been hampered by low yields of cell isolation procedures. Here we introduce a double fluorescent reporter mouse model combined with an optimized bead perfusion protocol and efficient single cell dissociation yield...
ORGANISM(S): Mus musculus 
2012-11-30 | E-GEOD-39441 | biostudies-arrayexpress
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