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GenomicsA Cbx8-containing Polycomb complex facilitates gene activation during ES cell differentiation [ChIP-Seq]
Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Here, we show that several differentiation genes tr...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-54052 | biostudies-arrayexpress
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
TranscriptomicsA Cbx8-containing Polycomb complex facilitates gene activation during ES cell differentiation [Agilent Array]
Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Here, we show that several differentiation genes tr...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-54051 | biostudies-arrayexpress
GenomicsEpo-Induced Erythroid Maturation Is Dependent on Plcγ1 Signaling
Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells into more committed progenitors and finally into erythrocytes. Binding of erythropoietin to its receptor (EpoR) is strictly required for erythropoiesis as it promo...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-60087 | biostudies-arrayexpress
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