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TranscriptomicsIdentification of chromatin interactions of 49 selected cellular loci prior to and post induction of BZFL1 in DG75 cells using the Capture-C technology.
Identification of specific chromatin interactions of 49 selected genes with the Capture-C technique in DG75 iBZLF1 cells prior to and 15 h after expression of EBV's protein BZLF1. The experiments were performed as triplicates.
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-8427 | biostudies-arrayexpress
TranscriptomicsRNA-seq data from DG75 cells with inducible BZLF1 prior to and after induction of EBV's lytic cycle by doxycycline.
(i) Transcripts of DG75 iBZLF1 cells were analyzed comparing non-induced cells and cells induced with doxycycline (100 ng/ ml) for 6 h. Doxycycline induces the expression of the full length viral transcription factor BZLF1. (ii) For control purposes, the transcripts of DG75 cells equipped with a dox...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-8426 | biostudies-arrayexpress
TranscriptomicsChIP-seq data from DG75 cells with the BZLF1 specific antibody BZ1
ChIP-seq experiments with the antibody BZ1 directed against the EBV protein BZLF1 prior to and 15 hours post induction with doxycycline (100 ng/ml). The doxycycline regulated conditional BZLF1 allele is encoded by an inducible oriP plasmid vector stably introduced into DG75 cells. Experiments were p...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-8422 | biostudies-arrayexpress
TranscriptomicsCapture-C identification of chromatin interactions of 53 selected cellular loci prior to and post induction of EBV's lytic cycle in Raji cells
Identification of specific chromatin interactions of 53 selected genes with the Capture-C technique in Raji iBZLF1 cells prior to and 6 or 15 h after induction of EBV’s lytic cycle. The experiments were performed as triplicates.
ORGANISM(S): Homo sapiens 
2019-04-05 | E-MTAB-7825 | biostudies-arrayexpress
TranscriptomicsRNA-seq in Raji cells with inducible BZLF1 prior to and after induction of EBV's lytic cycle by doxycycline
(i) RNA transcripts of Raji iBZLF1 cells (https://www.biorxiv.org/content/10.1101/573659v1) were compared between non-induced cells and cells induced with doxycycline (100 ng/ ml) for 6 h. Human (Hg19) as well as viral (EBV, Raji KF717093.1) transcripts were analyzed. Artificial ERCC Spike-ins (Ther...
ORGANISM(S): Homo sapiens 
2019-01-01 | E-MTAB-7820 | biostudies-arrayexpress
TranscriptomicsChIP-seq against BZLF1 in DG75 cells (EBV-negative, human Burkitt lymphoma cell line)
The parental DG75 cell line is EBV negative and cannot express the viral BZLF1 protein, thus, this set of experiments served as a negative control. After ChIP, peaks were identified in both the human and viral (EBV (Human Herpesvirus 4) genome KF717093.1) genome. Only few peaks were identified. Expe...
ORGANISM(S): Homo sapiens 
2019-04-05 | E-MTAB-7821 | biostudies-arrayexpress
TranscriptomicsInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
B cells from anonymous adenoid donors were isolated and sorted for naïve B cells, which were subsequently infected with a reference EBV strain (2089_B95-8) using a defined multiplicity of infection. Infection of resting B cells with EBV induces their activation, their proliferation, and subsequent i...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7805 | biostudies-arrayexpress
TranscriptomicsChIP-seq against the CTCF protein in Raji cells with inducible BZLF1 protein (KF717093.1) prior to and post induction of BZLF1.
Peaks were identified in both the human and viral (EBV (Human Herpesvirus 4; GenBank accession KF717093.1) genome.
ORGANISM(S): Homo sapiens 
2019-04-01 | E-MTAB-7787 | biostudies-arrayexpress
TranscriptomicsChIP-seq against BZLF1 in Raji cells (EBV, Human Herpesvirus 4, GenBank accession KF717093).
ChIP-seq experiments with the antibody BZ1 directed against the EBV protein BZLF1 prior to and 15 hours post induction with doxycycline (100 ng/ml). The doxycycline regulated conditional BZLF1 allele is encoded by an inducible plasmid stably introduced into Raji cells. Experiments were performed as ...
ORGANISM(S): Homo sapiens 
2019-04-01 | E-MTAB-7788 | biostudies-arrayexpress
GenomicsChIP-seq analysis with an antibody directed against the human H3K4me1 protein in Raji cells (Genbank: KF717093.1) prior to and post induction of BZLF1.
Peaks were identified in both the human and viral (EBV (Human Herpesvirus 4 GenBank accession KF717093.1) genome.
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-8425 | biostudies-arrayexpress
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