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Proteomics,MultiomicsMudPIT analyses of the proteins associated with IFZK3 and IFZK1 in a human multiple myeloma cell line, ARP-1
IKZF1 and IKZF3 are transcription factors highly expressed in myeloma and contribute to myeloma cell survival. To better understand the function of IKZFs, we sought out to identify novel physiologic partners. To this purpose we generated a human MM cell line, ARP-1, stably expressing physiologic l...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-13 | MSV000081712 | MassIVE
ProteomicsCRL4-DCAF15 control of cohesin dynamics sustains 1 cell proliferation
The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using a domain-focused genetic screening approach, we rev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-19 | MSV000092697 | MassIVE
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