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Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsScRNA-seq analysis of naive, germinal center and memory B cells of mice immunized with homologous and heterologous prime:boost combinations of whole-cell pertussis or acellular pertussis vaccines
Since the introduction of new generation pertussis vaccines, resurgence of pertussis is observed in many developed countries. Former whole-cell pertussis vaccines (wP) are able to protect against disease and transmission but have been replaced in several industrialized countries because of their rea...
ORGANISM(S): Mus musculus 
2022-09-12 | E-MTAB-12156 | biostudies-arrayexpress
TranscriptomicsImpact of Hells loss-of-function on DNA methylation in B cells during humoral immune responses: kinetic comparison of Mb1-Hells knockout and control mice by single-cell RNA sequencing
We are interested in deciphering the mechanism by which DNA methylation in late B cell differentiation affects humoral immune response. We chose to study a very rare immunodeficiency called ICF type 4, where a point mutation in a gene encoding the protein HELLS causes a lack of both circulating anti...
ORGANISM(S): Mus musculus 
2023-07-25 | E-MTAB-12499 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory and lethal infection in zebrafish embryos. To characterize the embryonic innate host response at the transcriptome level, we have extended and validated previous microarray data by Illumina next-generation sequen...
ORGANISM(S): Danio rerio 
2010-10-25 | E-GEOD-22472 | biostudies-arrayexpress
UnknownTargeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants.
Not available
S-EPMC10327284 | biostudies-literature
UnknownAssociations of Nocturnal Blood Pressure With Cognition by Self-Identified Race in Middle-Aged and Older Adults: The GENOA (Genetic Epidemiology Network of Arteriopathy) Study.
Not available
S-EPMC5721781 | biostudies-literature
UnknownHLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype.
Not available
S-EPMC9380401 | biostudies-literature
UnknownComplete Genome Sequence of the Ice-Nucleation-Active Pseudomonas syringae pv. pisi Isolate MUP32, Isolated from Frost-Damaged Pea (Pisum sativum subsp. arvense cv. Dundale) in New South Wales.
Not available
S-EPMC10019153 | biostudies-literature
TranscriptomicsSingle-cell sequencing of cerebral organoids with familial Alzheimer’s disease (AD) mutation in PSEN1 and non-demented control
We set up a 3D model based on iPSCs derived from patients with familial forms of Alzheimer’s disease (AD) and healthy non-demented control. We created cerebral organoids (COs), verified their ability to mimic AD in vitro, and used it to explore early events and the progression of AD pathogenesis. Ou...
ORGANISM(S): Homo sapiens 
2022-07-01 | E-MTAB-11438 | biostudies-arrayexpress
UnknownVascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging.
Not available
S-EPMC12505041 | biostudies-literature
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