The gut microbiota plays a crucial role in insect immune priming, inducing memory-like response that functionally resembles adaptive immunity confined to vertebrates. While gut microbiota mediates systemic immune activation in insect hemolymph, the mechanisms underlying remote immunoregulation re...
Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.
for this association remains incompletely understood. Diabetes-associated genes have been implicated in the control of central nervous system (CNS) disorders. In the current study, we observed a significant downregulation of secretagogin (SCGN) across multiple organs in diabetic mouse models. Con...
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...
This SuperSeries is composed of the following subset Series: GSE15107: R1 mESC Exposed to Butyrate GSE15109: BG02 hESC Exposed to Butyrate GSE15110: H1 hESC Exposed to Butyrate Refer to individual Series
Background Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is widely used for treating various malignancies. However, its clinical application is limited by dose-dependent cardiotoxicity (DOX-induced cardiotoxicity, DIC). Recent studies have shown that the gut microbiot...
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated NaM-CM-/ve CD4+ T cells from spleen of C57BL/6 mice and cultured the cells under Treg-indu...
