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MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
TranscriptomicsROS homeostasis and pimaricin production in Streptomyces natalensis ATCC 27448
The aim of this work was to unveil the molecular mechanisms by which Streptomyces respond to a ROS intracellular imbalance and the effect of such response on the biosynthesis of secondary metabolites. The study was focused on the industrial actinomycete S. natalensis ATCC 27448 producer of the polye...
ORGANISM(S): Streptomyces natalensis ATCC 27448 
2014-01-15 | E-GEOD-46537 | biostudies-arrayexpress
UnknownAnticancer response to disulfiram may be enhanced by co-treatment with MEK inhibitor or oxaliplatin: modulation by tetrathiomolybdate, KRAS/BRAF mutations and c-MYC/p53 status.
Not available
S-EPMC6369974 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis mature leaves were infiltrated with AZC or L-Proline (control of AZC) and tunicamycin or DMF(solvent control of tunicamycin) to investigate plant response to misfolded protein in the cytosol
Virus infection and over expression of protein in cytosol induce a subset of HSP70s. We named this response the Cytosolic Protein Response (CPR) and have been investigating it in the context of a parallel mechanism in the soluble cytosol with the UPR, and as a subcomponent of the larger HS response....
ORGANISM(S): Arabidopsis thaliana 
2009-01-13 | E-GEOD-11758 | biostudies-arrayexpress
ProteomicsBiophysical, proteomic, and lipidomic characterization of Streptococcus mutans extracellular membrane vesicles from wild-type, ΔsrtA, and Δsfp strains provides novel information regarding vesiculogenesis and its function
Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is largely unknown. In this study, we isolated and characterized EMVs derived from the oral pathogen Streptococcus mutans and two deletion mutants, ΔsrtA and Δsfp. ΔsrtA E...
ORGANISM(S): Streptococcus mutans serotype C 
2020-11-17 | PXD019825 | Pride
Vesicles Lipidome Proteome Streptococcus mutans Membrane 
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [array]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55130 | biostudies-arrayexpress
UnknownHighly Enantioselective Catalytic Lactonization at Nonactivated Primary and Secondary γ-C-H Bonds.
Not available
S-EPMC10507665 | biostudies-literature
TranscriptomicsForkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae [Sequence Data]
The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timing of specific origins is thought to reflect their chromatin environment or sub-nuclear positioning, how...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-20 | E-GEOD-33677 | biostudies-arrayexpress
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [ChIP-Seq]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55155 | biostudies-arrayexpress
GenomicsThe yeast Snt2 protein helps coordinate the transcriptional response to hydrogen-peroxide mediated oxidative stress (rapamycin or DMSO)
Snt2 is a yeast chromatin-interacting protein whose function has not been well characterized, that was recently shown to associate with Ecm5 and the Rpd3 deacetylase. Using chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq), we show that in response to H2O2, Snt2 and Ecm...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-24 | E-GEOD-43001 | biostudies-arrayexpress
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