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The identification of Atg16L1 as a susceptibility gene has implicated antibacterial autophagy in the pathogenesis of Crohn's disease, a major type of inflammatory bowel disease (IBD). However, the role of Atg16L1 during extracellular bacterial infections of the intestine has not been sufficiently ex...
ORGANISM(S): Mus musculus 
Purpose of this experiment was to gain insight into the transcriptional changes resulting from Atg5 deficiency in colonic goblet cells.
ORGANISM(S): Mus musculus 
Transcription profiling of Paneth cells from Atg16l1hm mice with CR6 virus
ORGANISM(S): Mus musculus 
Transcription profiling of Paneth cells from Atg16l1hm mice with CR6 virus. Normalized data is provided as an additional file on the FTP site for this experiment.
ORGANISM(S): Mus musculus 
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes ...
ORGANISM(S): Mus musculus 
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