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TranscriptomicsTRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis elegans
The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their ...
ORGANISM(S): Caenorhabditis elegans 
2016-04-01 | E-GEOD-77976 | biostudies-arrayexpress
ProteomicsThe C. elegans ASPP homolog APE-1 is a junctional Protein Phosphatase 1 modulator
Protein samples were analyzed by Multidimensional Protein Identification Technology (MudPIT), as described previously. Briefly, precipitated proteins were resuspended in 30uL of 100mM Tris pH 8.5 with 8M urea to denature proteins. Cysteines were reduced and alkylated prior to digestion with recombi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Caenorhabditis Elegans (ncbitaxon:6239) 
2022-02-04 | MSV000088781 | MassIVE
TranscriptomicsExpression data from C. elegans wild type, hlh-25 mutant and hlh-29 mutant strains
In Caenorhabditis elegans, the six proteins that make up the REF-1 family are HES homologs that act in both Notch dependent and Notch-independent pathways to regulate embryonic events. To further our understanding of how the REF-1 family works to coordinate post-embryonic cellular events, we perfor...
ORGANISM(S): Caenorhabditis elegans 
2016-07-03 | E-GEOD-65417 | biostudies-arrayexpress
UnknownRedox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1.
Not available
S-EPMC6449771 | biostudies-literature
GenomicsMitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans
Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans
PRJNA1369544 | ENA
GenomicsCaenorhabditis elegans
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis elegans
PRJNA312237 | ENA
ProteomicsPeroxiredoxin 2 is required for the exercise induced redox mediated adaptation to exercise
During exercise there is a site-specific increase in ROS within muscle required for the beneficial adaptive response by activation of specific signalling pathways. Peroxiredoxin 2 (Prdx2), an abundant cytoplasmic 2-Cys peroxidase, is required for the adaptive beneficial hormesis response to H2O2, my...
ORGANISM(S): Caenorhabditis elegans 
2023-03-11 | PXD037698 | Pride
Caenorhabditis elegans redox 
UnknownIn Vivo Detection of Reactive Oxygen Species and Redox Status in Caenorhabditis elegans.
Not available
S-EPMC5041511 | biostudies-literature
UnknownMitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.
Not available
S-EPMC9709155 | biostudies-literature
ProteomicsMitochondria preconditioning delays aging and associated diseases in C. elegans impacting on key ferroptosis players
Excessive iron accumulation or deficiency have detrimental consequences across species, leading to a variety of pathologies in humans. In the nematode Caenorhabditis elegans severe iron as well as oxygen deprivation induce developmental arrest. Instead, hypoxia preconditioning protects against sever...
ORGANISM(S): Caenorhabditis elegans 
2023-04-17 | PXD040724 | Pride
Aging  c. elegans  fatty acids  ferroptosis  frataxin  hypoxia  iron  mitochondria  neurodegeneration  oxidoreductase 
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