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TranscriptomicsLysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
Lysine Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4), but has coactivator function on some genes through unclear mechanisms. We show that LSD1, interacting with CoREST, associates with and coactivates androgen recep...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-52201 | biostudies-arrayexpress
GenomicsGenome-wide maps of AR binding in prostate cancer cell lines VCaP and VCS2
We report the high-throughput profiling of AR binding in prostate cancer cells. Examination of AR binding in prostate cancer cell lines VCaP and VCS2
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-32345 | biostudies-arrayexpress
ProteomicsFOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
For FLAG pull-down, protein extracts of cells stably expressing FLAG-tagged FOXA2 were incubated with FLAG-conjugated beads. To perform mass spectrometry analysis, we used at least 6 x 108 cells to map post-translational modification sites through Thermo EASY-nLC 1200 at the Proteomics Core of Unive...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-15 | MSV000094773 | MassIVE
GenomicsGenome-wide mapping of retinoblastoma (Rb) binding sites in prostate cancer cell lines VCaP and LNCaP
Although well characterized as a transcriptional activator, androgen receptor (AR) can also function as a direct transcriptional repressor in prostate cancer cells. The major targets of the AR repressive function are genes mediating DNA synthesis. In this study, we found that AR was recruited to th...
ORGANISM(S): Homo sapiens 
2015-12-19 | E-GEOD-76141 | biostudies-arrayexpress
TranscriptomicsExpression profiling of prostate cancer VCaP and VCS2
Microarray experiments were performed for VCaP and VCS2 cells with and without androgen stimulation The RNA samples were extracted from VCaP and VCS2 cells treated with Ethanol or 10nM DHT for 24 hours. RNA was submitted to Dana-Farber Cancer Institute Microarray Core Facility for hybridyzation.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-32344 | biostudies-arrayexpress
TranscriptomicsAndrogen Receptor Gene Expression in Prostate Cancer is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine Specific Demethylase 1
Androgen receptor (AR) is reactivated in castration resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to increased AR expression at low androgen levels in CRPC. Moreover, at increased and...
ORGANISM(S): Homo sapiens 
2011-08-15 | E-GEOD-31410 | biostudies-arrayexpress
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