Sort   by:  
 Page size 
UnknownUtilizing network pharmacology and experimental validation to investigate the underlying mechanism of phellodendrine on inflammation.

Background

Phellodendrine, one of the characteristic and important active components of Cortex phellodendri, has been proven to show anti-inflammatory effects. However, the underlying mechanism of phellodendrine on inflammation remains largely unclear.

Aim of the study

In this study, ...
S-EPMC9512003 | biostudies-literature
UnknownmiR-136 Regulates the Proliferation and Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions by Targeting HSD17B12.
Fat deposition involves the continuous differentiation of adipocytes and lipid accumulation. Studies have shown that microRNA miR-136 and 17β-hydroxysteroid dehydrogenase type 12 (HSD17B12) play important roles in lipid accumulation. However, the regulatory mechanism through which miR-136 tar...
S-EPMC10573499 | biostudies-literature
UnknownCircRNA Profiling of Skeletal Muscle in Two Pig Breeds Reveals CircIGF1R Regulates Myoblast Differentiation via miR-16.
Muscle development is closely related to meat quality and production. CircRNAs, with a closed-ring structure, have been identified as a key regulator of muscle development. However, the roles and mechanisms of circRNAs in myogenesis are largely unknown. Hence, in order to unravel the functions of ci...
S-EPMC9965117 | biostudies-literature
UnknownFNDC5 Promotes Adipogenic Differentiation of Primary Preadipocytes in Mashen Pigs.
Fibronectin type III domain-containing protein 5 (FNDC5) plays an important role in fat deposition, which can be cut to form Irisin to promote fat thermogenesis, resulting in a decrease in fat content. However, the mechanism of FNDC5 related to fat deposition in pigs is still unclear. In this resear...
S-EPMC9858987 | biostudies-literature
UnknownIntegrated metabolic, transcriptomic and chromatin accessibility analyses provide novel insights into the competition for anthocyanins and flavonols biosynthesis during fruit ripening in red apple.
Fruit ripening is accompanied by a wide range of metabolites and global changes in gene expression that are regulated by various factors. In this study, we investigated the molecular differences in red apple 'Hongmantang' fruits at three ripening stages (PS1, PS5 and PS9) through a comprehensive ana...
S-EPMC9540549 | biostudies-literature
UnknownMachine learning methods for predicting human-adaptive influenza A virus reassortment based on intersegment constraint.

Introduction

It is not clear about mechanisms underlining the inter-segment reassortment of Influenza A viruses (IAVs).We analyzed the viral nucleotide composition (NC) in coding sequences,examined the intersegment NC correlation, and predicted the IAV reassortment using machine learning (ML...
S-EPMC11970406 | biostudies-literature
UnknownTomato SlWRKY3 Negatively Regulates Botrytis cinerea Resistance via TPK1b
Not available
S-EPMC11207927 | biostudies-literature
UnknownGlobal Potential Distribution of Invasive Species Pseudococcus viburni (Hemiptera: Pseudococcidae) under Climate Change.
The potential distribution range and management strategies for P. viburni are poorly understood. Based on historical distribution data and environmental factors, the present study predicted the potentially suitable areas for P. viburni spread under different climate change scenarios us...
S-EPMC10971524 | biostudies-literature
UnknownGenetic Diversity and Selection Signatures of Lvliang Black Goat Using Genome-Wide SNP Data.
Lvliang black goat (LBG) is an excellent local breed resource in China that is known for its black fur, excellent meat quality, and strong adaptability. Studying the genetic mechanism and germplasm characteristics of LBG can provide theoretical and practical basis for the protection of the genetic r...
S-EPMC11544794 | biostudies-literature
UnknownPolytorsional-amide/carboxylates-directed Cd(ii) coordination polymers exhibiting multi-functional sensing behaviors.
By rational assembly of polytorsional-amide [N,N'-bis(4-methylenepyridin-4-yl)-1,4-naphthalene dicarboxamide (L)] and polytorsional-carboxylates [H2ADI = adipic acid, H2PIM = pimelic acid, H2SUB = suberic acid], three new Cd-based coordination polymers ...
S-EPMC9041708 | biostudies-literature
Sort   by:  
 Page size