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MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
MetabolomicsGNPS hormaomycin (Streptomyces griseoflavus W384)
LC-MS analysis of LC purified hormaomycin Reference: Cai X, Teta R, Kohlhaas C, Cr�semann M, Ueoka R, Mangoni A, Freeman MF, Piel J., Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis. Chem Biol. 2013 Jun 20;20(6):839-46.
ORGANISM(S): Streptomyces Griseoflavus W384 
2014-05-23 | MSV000078668 | GNPS
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
UnknownTenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer.
Not available
S-EPMC5650351 | biostudies-literature
UnknownAilanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation.
Not available
S-EPMC11365432 | biostudies-literature
UnknownIn vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun.
Not available
S-EPMC7610543 | biostudies-literature
UnknownWnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway.
Not available
S-EPMC7261892 | biostudies-literature
UnknownTumor-secreted LCN2 impairs gastric cancer progression via autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis.
Not available
S-EPMC11489581 | biostudies-literature
MetabolomicsUntargeted plasma metabolome identifies biomarkers in patients with extracranial arteriovenous malformations

OBJECTIVE: This study aimed to investigate the plasma metabolic profile of patients with extracranial arteriovenous malformations (AVM).

METHOD: Plasma samples were collected from 32 AVM patients and 30 healthy controls (HC). Ultra-high performance liquid c...

2023-10-30 | MTBLS7753 | MetaboLights
UnknownMannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.
Not available
S-EPMC11844275 | biostudies-literature
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