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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
TranscriptomicsRNA-seq of a developmentally retarded Chinese cabbage (Brassica campestris ssp. pekinensis) mutant
The leaf of Chinese cabbage is the major place of photosynthesis, the mutation of leaf may directly affect the rate of plant growth and development and the formation of leafy head, and ultimately influence the yield and quality of Chinese cabbage. We identified a developmentally retarded mutant (drm...
ORGANISM(S): Brassica rapa subsp. oleifera 
2016-03-01 | E-GEOD-75464 | biostudies-arrayexpress
UnknownFusarium diversity associated with diseased cereals in China, with an updated phylogenomic assessment of the genus.
Not available
S-EPMC10282163 | biostudies-literature
TranscriptomicsIdentification of genes associated with pistil development by transcriptome analysis of a female sterility mutant (fsm) in Chinese cabbage (Brassica campestris ssp. pekinensis)
The female sterility mutants are ideal materials for studying the pistil development in plants. We identified a female sterility mutant (fsm) exhibiting stable inheritance, which was derived from a Chinese cabbage DH line ‘FT’ using the combination of isolated microspore culture and ethyl methan...
ORGANISM(S): Brassica rapa subsp. pekinensis 
2016-06-02 | E-GEOD-76917 | biostudies-arrayexpress
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
UnknownUnlocking Li superionic conductivity in face-centred cubic oxides via face-sharing configurations.
Not available
S-EPMC10990923 | biostudies-literature
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
UnknownA new metallic π-conjugated carbon sheet used for the cathode of Li-S batteries.
Not available
S-EPMC9060888 | biostudies-literature
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