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TranscriptomicsTranscription profiling of in mouse medulloblastomas and generation of tumors from cerebellar grunule neuron precursors
Mice lacking p53 and one or two alleles of the cyclin D-dependent kinase inhibitor p18Ink4c are prone to medulloblastoma development. The tumor frequency is increased by exposing postnatal animals to ionizing radiation at a time when their cerebella are developing. In irradiated mice engineered to e...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6463 | biostudies-arrayexpress
UnknownMetabolic shift underlies recovery in reversible infantile respiratory chain deficiency
Not available
S-SCDT-EMBOJ-2020-105364-T | biostudies-other
TranscriptomicsPreclinical Models for Neuroblastoma: Establishing a Baseline for Treatment
Here we characterize and optimize both systems to increase their utility for preclinical studies. We show that TH-MYCN mice develop tumors in the paraspinal ganglia, but not in the adrenal, with cellular and gene expression patterns similar to human NB. In addition, we present a new ultrasound guide...
ORGANISM(S): Mus musculus 
2011-03-17 | E-GEOD-27516 | biostudies-arrayexpress
TranscriptomicsIn vivo electroporation-based conditional oncogenic activation implicates multiple distinct cellular origins for Group3 medulloblastoma
We examined the transformation susceptibility of different cerebellar stem/progenitors by developing several new Group3 medulloblastoma murine models using orthotopic transplantation and in utero electroporation (EP)-based in vivo gene transfer with Cre/LoxP-mediated conditional Myc gene activation ...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65888 | biostudies-arrayexpress
TranscriptomicsGTF2I Mutations are Common in Thymic Epithelial Tumors
Within a project aim to define the genomic aberration of thymic epithelial tumors, we performed array CGH in 65 thymic epithelial tumors. Tumor samples were collected during surgery or by image-guided biopsies and immediately frozen. Section from frozen material were cut and stained with Haematoxyli...
ORGANISM(S): Homo sapiens 
2014-06-21 | E-GEOD-55852 | biostudies-arrayexpress
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