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MetabolomicsCombined metabolomics with transcriptomics reveals important serum biomarkers correlated with lung cancer proliferation through calcium signaling pathway

Lung cancer (LC) is still one of the most deadly cancers in the world, but there is a lack of non-invasive biomarkers to assist diagnosis and guide treatment. Herein, untargeted serum metabolomics of 57 LC patients and 59 HC people was performed based on gas chromatography-mass spectrography (GC-...

2025-04-29 | MTBLS1517 | MetaboLights
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
TranscriptomicsInflammatory mediators alter astrocyte genomic profiles and G-protein receptor evoked calcium signaling
Inflammation features in diverse central nervous system disorders such as stroke, trauma, neurodegeneration, infection and autoimmunity. To better understand how inflammatory mediators may alter astrocyte functions, we examined the effects of transforming growth factor-β1 (TGF-β1), lipopolysacchar...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-36089 | biostudies-arrayexpress
ModelsKummer2000 - Oscillations in Calcium Signalling
Kummer2000 - Oscillations in Calcium Signalling Simplified (3-variable) calcium oscillation model Kummer et al. (2000) Biophys. J. 79, 1188-1195 This model is defined in a small compartment with low concentrations. You can run it first with the LSODA ODE solver and then with the Gillespie M...
2024-09-02 | BIOMD0000000329 | BioModels
TranscriptomicsIdentification of the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans
Microarray analysis was used to identify the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans. In order to identify such genes, we conducted the two types of experiment. One was a comparison between wild type with calcium treatment and wild type without cal...
ORGANISM(S): Emericella nidulans 
2008-10-02 | E-GEOD-12953 | biostudies-arrayexpress
GenomicsHomeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit
PRJNA701007 | ENA
Transcriptomicsnuclear calcium regulated genes in spinal neurons during inflammatory pain
Identification of a pain-associated, nuclear calcium-regulated gene program in spinal excitatory neurons during inflammatory pain, using a nucleus-specific calcium signal perturbation strategy in vivo complemented by gene profiling
ORGANISM(S): Mus musculus 
2013-12-13 | E-MTAB-1416 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis seedlings response to oscillations and prolonged increases in cytosolic Ca2+
Comparison of two types of calcium signature produced by application of voltage in Arabidopsis thaliana seedlings; namely oscillations or prolonged increase in cytosolic Ca2+ , each treatment is a biological dyeswap compared to untreated control
ORGANISM(S): Arabidopsis thaliana 
2010-08-01 | E-MEXP-2659 | biostudies-arrayexpress
ModelsLeBeau1999 - IP3-dependent intracellular calcium oscillations due to agonist stimulation from Cholecytokinin
The properties of inositol 1,4,5-trisphosphate (IP3)-dependent intracellular calcium oscillations in pancreatic acinar cells depend crucially on the agonist used to stimulate them. Acetylcholine or carbachol (CCh) cause high-frequency (10–12-s period) calcium oscillations that are superimposed on a ...
2024-09-02 | BIOMD0000000965 | BioModels
TranscriptomicsOscillations in supercoiling drive circadian gene expression in cyanobacteria
The cyanobacterium Synechococcus elongatus PCC 7942 exhibits oscillations in mRNA transcript abundance with 24-hour periodicity under continuous light conditions. The mechanism underlying these oscillations remains elusive â?? neither cis nor trans-factors controlling circadian gene expression phase...
ORGANISM(S): Synechococcus elongatus PCC 7942 
2010-05-19 | E-GEOD-18902 | biostudies-arrayexpress
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