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GenomicsHigh-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary ...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-42518 | biostudies-arrayexpress
UnknownCharacterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.
Not available
S-EPMC3796878 | biostudies-literature
GenomicsThe Growth factor independence 1 (GFI1) 36N variant predisposes to Acute Myeloid Leukemia (AML) by inducing epigenetic changes at the Hoxa9 locus
GFI136N is a coding Single Nucleotide Polymorphism (SNP) in the gene GFI1 that increases the risk for Acute myeloid leukemia (AML) by 60%. It is present in 3-5% of Caucasians and has a prevalence of 12% among AML patients. We generated knockin mice expressing either the human GFI136N variant or the ...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-31657 | biostudies-arrayexpress
UnknownCombined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations.
Not available
S-EPMC4460190 | biostudies-literature
TranscriptomicsMolecular signatures of heterogeneous stem cell populations are resolved by linking single cell functional assays to single cell gene expression
The discovery of significant heterogeneity in the self-renewal durability of adult haematopoietic stem cells (HSCs) has challenged our understanding of the molecules involved in population maintenance throughout life. Gene expression studies in bulk populations are difficult to interpret since mult...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-61533 | biostudies-arrayexpress
ProteomicsProteomic analysis of circulating immune cells identifies novel cellular phenotypes associated with COVID-19 severity
Certain serum proteins, including CRP and D-dimer, have prognostic value in patients with SARS-CoV-2 infection. Nonetheless, these factors are non-specific, and provide limited mechanistic insight into the peripheral blood mononuclear cell (PBMC) populations which drive the pathogenesis of severe CO...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD040703 | Pride
Covid-19 Pbmc Cell surface Sars-cov-2 Plasma membrane Phenotype Biomarker 
UnknownEnhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Not available
S-EPMC6545840 | biostudies-literature
UnknownNotch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Not available
S-EPMC7156969 | biostudies-literature
UnknownThe PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models.
Not available
S-EPMC11348616 | biostudies-literature
UnknownProteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity.
Not available
S-EPMC10243220 | biostudies-literature
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