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TranscriptomicsA complementary role for ELF3 and TFL1 in the regulation of flowering time by ambient temperature, in Arabidopsis thaliana.
Plants regulate their time to flowering by gathering information from the environment. Photoperiod and temperature are among the most important environmental variables. Suboptimal, but not near-freezing, temperatures regulate flowering through the thermosensory pathway, which overlaps with the auton...
ORGANISM(S): Arabidopsis thaliana 
2009-04-18 | E-GEOD-15689 | biostudies-arrayexpress
TranscriptomicsPFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis
Two aspects of light are very important for plant development: the length of the light phase or photoperiod and the quality of incoming light. Photoperiod detection allows plants to anticipate the arrival of the next season, whereas light quality, mainly the red to far-red ratio (R:FR), is an early ...
ORGANISM(S): Arabidopsis thaliana 
2012-04-02 | E-GEOD-37014 | biostudies-arrayexpress
GenomicsTumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
PRJNA1036165 | ENA
TranscriptomicsExpression profiling of Burkitt's lymphoma cells 24h after FOXM1 shRNA or MYB shRNA lentivirus-mediated transduction
Human Burkitt's lymphoma ST486 cells were transduced with non-target control shRNA lentiviral vectors, FOXM1 shRNA, and MYB shRNA lentiviral vectors. Total RNA was isolated 24h later. cRNA was produced with the standard one-step IVT protocol (Affymetix) and hybridized in U95Av2 gene chips (Affymetr...
ORGANISM(S): Homo sapiens 
2009-07-27 | E-GEOD-17172 | biostudies-arrayexpress
GenomicsTherapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
PRJNA926592 | ENA
GenomicsTherapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
PRJNA926996 | ENA
TranscriptomicsRegulation of extraembryonic endoderm stem cell differentiation by Nodal and EGF-CFC signaling
The signaling pathway for Nodal, a ligand of the transforming growth factor-beta (TGF-beta) superfamily, plays a central role in regulating the maintenance and/or differentiation of stem cell types that can be derived from the peri-implantation mouse embryo. Extraembryonic endoderm stem (XEN) cells ...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-23675 | biostudies-arrayexpress
TranscriptomicsLineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epithelial basal cells to those originated from luminal cells. We next generated expression signatures for both basal and luminal origin tumors by comparison of tumor samples to their respective controls. By ...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-39509 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ErbB2-engineered MCF10A and WT cells
Gene expression profiling of ErbB2-engineered MCF10A and WT cells in 2D and 3D culture Gene expression profiling of ErbB2-engineered MCF10A and WT cells, 2D and 3D culture, 5 or 6 replicates
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-62250 | biostudies-arrayexpress
TranscriptomicsIL6-STAT3 downstream targets in MCF10A/MCF10A.ErbB2* cells
Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB2* with/without shRNA targeting STAT3 Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB* with/without shSTAT3, duplicates, two STAT3 shRNAs
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-62235 | biostudies-arrayexpress
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