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TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
ModelsLi2019 - Neurogranin stimulates Ca/calmodulin-dependent kinase II by inhibiting Calcineurin
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its complex, and sometimes opposite, influences via the binding to various proteins are yet to be fully understood. Calcium/calmodulin-dependent protein kinase II (CaMKII) and calcineurin (CaN) both bind open calmo...
2019-12-18 | MODEL1903010001 | BioModels
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
ModelsStefan2008 - calmodulin allostery
Stefan2008 - calmodulin allostery An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed (R)] state. This model is described in the article: An allosteric model o...
2024-09-02 | BIOMD0000000183 | BioModels
TranscriptomicsmicroRNA-1 negatively regulates expression of the hypertrophy-associated genes calmodulin and Mef2a
Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes is limiting, precise regulation of calmodulin expression may be an important for regulation of calcium signaling...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13874 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profile of antigen receptor activated B cells expressing wildtype or Calmodulin (CaM) - resistant E12
To elucidate the genome-wide role of Ca2+/ calmodulin inhibition of E2A in regulation of BCR activation, we performed DNA microarray analysis of activated splenic B cells expressing wildtype or CaM-resistant E12 mutant m8N47 with and without anti-IgM treatment for 3 hour.The expression of a remarkab...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-35747 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hippocampi from wild type and alpha-CaMKII+/- mice
Comparison of the hippocampus of alpha-CaMKII+/- mice with control
ORGANISM(S): Mus musculus 
2008-10-04 | E-MEXP-962 | biostudies-arrayexpress
TranscriptomicsA Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning
Trancript Based Cloning (TBC) uses standard Gene Expression techniques to quickly isolate genes of interest and begin to determine their function. Using a particular mutant phenotype, identified during a programme of mutagenesis and screning, and a wild-type control we can quickly determine a list o...
ORGANISM(S): Hordeum vulgare 
2011-11-22 | E-GEOD-33397 | biostudies-arrayexpress
UnknownConformational changes underlying calcium/calmodulin-dependent protein kinase II activation.
Not available
S-EPMC3094114 | biostudies-literature
ProteomicsStructural Analysis of Hippocampal Kinase Signal Transduction
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolu...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2018-05-23 | MSV000082390 | MassIVE
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