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MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
MetabolomicsGut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-f...
2022-04-01 | MTBLS4431 | MetaboLights
MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
MetabolomicsCNS and peripheral metabolomics of calorie restriction in a mouse model of Alzheimer’s disease (part II)
Not available
ORGANISM(S): Mus musculus 
ST000463 | MetabolomicsWorkbench
MetabolomicsCNS and peripheral metabolomics of calorie restriction in a mouse model of Alzheimer’s disease (part I)
Not available
ORGANISM(S): Mus musculus 
ST000462 | MetabolomicsWorkbench
MetabolomicsA high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the ...

2025-06-13 | MTBLS12479 | MetaboLights
TranscriptomicsTranscription profiling of cochleae from young and middle aged mice subjected to calorie restriction to examine age-related changes and calorie restriction-induced changes in gene expression in the cochlea.
Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late on...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4786 | biostudies-arrayexpress
TranscriptomicsCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress
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