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TranscriptomicsTranscriptional profiling of ovarian cancer samples with different grades
We have previously demonstrated (Calura E et al., 2013) that different epithelial ovarian cancer (EOC) histotypes have different, defined characteristics at the microRNA level, which might highlight a different originating tissue for the disease. From these results we have invesigated whole-genome g...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1814 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [PCL, gene]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-73452 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [PCL, miRNA]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-73454 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [MM, miRNA]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-70254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, sco1 and sco2 knock out mutants of S. cerevisiae BY4741 in early response to different doses of oleic acid
This experiment describes the transcriptional response to oleic acid as a sole carbon source of yeast strains differing in their respiratory competence: the BY4741 wild type strain is considered as normal, sco1 knock out mutant is respiratory deficient and sco2 knock out mutant has a better respirat...
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-31 | E-TABM-614 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [MM, gene]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-70319 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition, simulated by a ground-based Rotating Wall Vessel (RWV) bioreactor. Our results show that 42 miRNAs were differentially expressed in MMG-incubated PBLs...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-57400 | biostudies-arrayexpress
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
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