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TranscriptomicsA promoter DNA demethylation landscape of human hematopoietic differentiation
Global mechanisms defining the gene expression programs specific for hematopoiesis are still not fully understood. Here, we show that promoter DNA demethylation is associated the activation of hematopoietic-specific genes. Using genome-wide promoter methylation arrays, we identified 694 hematopoie...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30090 | biostudies-arrayexpress
TranscriptomicsExpression data of human fetal liver hematopoietic stem and progenitors cells [Set 2]
Advances in pluripotent stem cell and reprogramming technologies have given hope of generating hematopoietic stem cells (HSC) in culture. To succeed, greater understanding of the self-renewing HSC during human development is required. We discovered that glycophosphatidylinositol-anchored surface pro...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-54315 | biostudies-arrayexpress
TranscriptomicsExpression data of human fetal liver hematopoietic stem and progenitors cells [Set 1]
Advances in pluripotent stem cell and reprogramming technologies have given hope of generating hematopoietic stem cells (HSC) in culture. To succeed, greater understanding of the self-renewing HSC during human development is required. We discovered that glycophosphatidylinositol-anchored surface pro...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-54314 | biostudies-arrayexpress
TranscriptomicsExpression data of human fetal liver hematopoietic stem and progenitors cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-54316 | biostudies-arrayexpress
GenomicsNuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/?-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of Wnt/?-catenin signaling that also has undefined ?-catenin-independent actions. Here we report for the first time that a proportion of DKK...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-31170 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes
Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from twelve 53–80 year-old monozygotic discordant twin pa...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-38291 | biostudies-arrayexpress
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