Sort   by:  
 Page size 
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
Rats were randomly assigned to one of two different groups, a control (C, n=6) group that received a saline enema and a TNBS group (n=6) that received the TNBS challenge. Colonic epithelial cells were isolated from the distal colon of control and TNBS (non necrosed) rats by calcium chelation and per...
ORGANISM(S): Rattus norvegicus 
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
Sort   by:  
 Page size