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ProteomicsCOS7 GlyT2 variants associated with hyperekplexia
Multiplexed LC-MS/MS analysis of heterologous cells expressing a new GlyT2 variant found in an infantile patient diagnosed with hyperekplexia.
ORGANISM(S): Chlorocebus sabaeus 
2025-08-04 | PXD061845 | Pride
Co7 cells Glyt2 variants 
ProteomicsDll4iDEC mouse liver endothelial cells
Myc and its target Odc1 were among the most 250 strongly upregulated genes in Dll4 mutant ECs, compared with Notch1 and Rbpj mutants. Myc is known to activate important ribosome biogenesis and protein translation pathways, favoring cell growth. Dll4iDEC livers showed upregulation of a large range of...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD041349 | Pride
Dll4idec liver endothelial cells Quantitative proteomics 
ProteomicsMarfan mouse and human aortic tissue
Thoracic aortic aneurysms and dissections (TAAD), as occur in Marfan syndrome (MFS), currently lack a cure. Our previous studies revealed that overactivation of the AKT-NO signaling pathway mediates aortic disease in MFS. However, the mechanisms upstream of AKT activation remained poorly understood....
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-06-02 | PXD077940 | Pride
Human Aortic tissue Mouse Marfan syndrome 
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