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TranscriptomicsYap role in intestine
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ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-41509 | biostudies-arrayexpress
TranscriptomicsExpression data from YAP-S127A Villin-rtTA crypts
We overexpressed YAP in the intestinal epithelium by adding doxycycline to the drinking water of experimental mice. Mice were given dox for 2 days, and referred to as Tg (transgenic). Mice were given dox for 2 days, sacrificed, and crypts were isolated for RNA extraction and analyzed by Affymetrix m...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41506 | biostudies-arrayexpress
TranscriptomicsExpression data from YAP-S127D DLD1 Xenografts
We overexpressed YAP-S127D in DLD1 colorectal cancer cells for 21 days after sub-cutaneous (SubQ) injection into the flanks of nude mice. Mice were given dox for 21 days, sacrificed, and tumors were isolated for RNA extraction and analyzed by Affymetrix microarrays.
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-41508 | biostudies-arrayexpress
TranscriptomicsRSpondin1 treatment of control and Yap cKO mice
RSpondin1 adenovirus was administered to mice and intestine was isolated for expression analysis 1 week later. Yap control and cKO mice were given Rspondin virus and sacrificed 1 week later.
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41507 | biostudies-arrayexpress
TranscriptomicsRole of Yes-Associated Protein 1 (YAP1) in rhabdomyosarcoma
Doxycycline-inducible YAP1 S127A-driven rhabdomyosarcoma (RMS) tumors, control skeletal muscle and regressed tumors following YAP1 normalization by doxycycline withdrawal were compared to determine the YAP1-regulated gene expression profile relevant to RMS formation. To characterize the role of YAP1...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-47198 | biostudies-arrayexpress
TranscriptomicsAnalysis of small RNAs in murine neutrophils by Solexa/Illumina genome analyzer
To examine the effects of microRNAs including miR-223 on murine neutrophil function, small RNAs cloning and sequencing from neutrophils were performed. Neutrophils were isolated from a wild-type mouse and total RNAs were prepared. Small RNAs were cloned and sequenced by Solexa/Illumina genome analy...
ORGANISM(S): Mus musculus 
2008-07-31 | E-GEOD-12074 | biostudies-arrayexpress
TranscriptomicsAnalysis of HeLa cells after transfection with miR-1, miR-124 and miR-181.
Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS. Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124,...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-11968 | biostudies-arrayexpress
TranscriptomicsGlobal microRNA expression analysis in mouse skin normal tissues and skin tumors induced by constitutive active YAP mutant.
Global downregulation of microRNAs (miRNAs) is commonly observed in human cancers and can have a causative role in tumorigenesis. The mechanisms responsible for this phenomenon remain poorly understood. Here we show that YAP, the downstream target of the tumor-suppressive Hippo signaling pathway reg...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-52206 | biostudies-arrayexpress
GenomicsThe Hippo tranducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation
The Hippo pathway effector YAP1 controls stem cell fate in epithelial tissues, but its role in stem cells of non-epithelial tissues, such as skeletal muscle, is poorly documented. Here we show that sustained YAP1 activity in mouse activated satellite cells in vivo induces rhabdomyosarcoma (RMS) rese...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-55186 | biostudies-arrayexpress
Transcriptomics3’-Seq of multipotent progenitor cells MPP5
Here, we present a 3'-Seq dataset of ex vivo isolated mouse multipotent progenitor cells MPP5
ORGANISM(S): Mus musculus 
2021-06-18 | E-MTAB-9135 | biostudies-arrayexpress
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