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MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
TranscriptomicsTranscription profiling of mouse S49 cells to study the global impact of cAMP and protein kinase A on gene expression
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A (PKA), on gene expression is not known. Here we show that treatment of wild-type S49 lymphoma cells for 24 h with 8-(4-chlorophenylthio)-cAM...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse S49 lymphoma cell deathless (D-) cell variant
The second messenger cAMP acts via protein kinase A (PKA) to induce apoptosis by mechanisms that are poorly understood. Here, we assessed a role for mitochondria and analyzed gene expression in cAMP/PKA-promoted apoptosis by comparing wild-type (WT) S49 lymphoma cells and the S49 variant, D- (cAMP-d...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9727 | biostudies-arrayexpress
TranscriptomicsS. cerevisiae mutant with a constitutively activated Ras/cAMP pathway
Comparison of the transcriptomes of Saccharomyces cerevisiae wild type FY23 and a PDE2 deletion mutant DJ28. Keywords = PDE2 Keywords = Ras/cAMP pathway
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-600 | biostudies-arrayexpress
TranscriptomicsPro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells
Human mesenchymal stromal cells (hMSCs) are able to differentiate into a wide variety of cell types, which makes them an interesting source for tissue engineering applications. On the other hand, these cells also secrete a broad panel of growth factors and cytokines that can exert trophic effects on...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7224 | biostudies-arrayexpress
GenomicsPlasmodium falciparum CAMP/Malaysia
Plasmodium falciparum Malayan Camp genome sequencing project
PRJNA67497 | ENA
TranscriptomicsTranscription profiling time series of the cAMP-induced decidualization of human endometrial stromal cells
Timecourse of cAMP-induced decidualization of endometrial stromal cells.

Note that files GSM5962.txt and GSM5965.txt as imported from GEO are identical.
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-403 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the rat pineal gland: dominant role of adrenergic/cAMP Signaling - super series
This SuperSeries is composed of the following subset Series:; GSE12341: Expt. A; Daily Rhythm in Expression of >600 Genes in the Rodent Pineal Gland: Dominant Role of Adrenergic/cAMP Signaling; GSE12342: Expt. B; Daily Rhythm in Expression of >600 Genes in the Rodent Pineal Gland: Dominant Role of A...
ORGANISM(S): Rattus norvegicus 
2009-01-23 | E-GEOD-12344 | biostudies-arrayexpress
TranscriptomicsDiverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...
ORGANISM(S): Homo sapiens 
2018-08-05 | E-MTAB-7038 | biostudies-arrayexpress
TranscriptomicsHelicobacter pylori induce miR-155 in T cells in a cAMP-Foxp3 dependant manner
The human pathogen Helicobacter pylori (Hp) colonizes the gastric epithelium as a unique niche in the stomach. Infections commonly occur in childhood and persist lifelong, leading in some cases to adenocarcinoma and MALT lymphoma. Several studies define mammalian microRNAs as key regulators of the i...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-18616 | biostudies-arrayexpress
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