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TranscriptomicsRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Recently, we defined four subtypes of pancreatic cancer that are associated with distinct histopathological characteristics and differential survival, namely, Squamous, Pancreatic Progenitor, Immunogenic, and ADEX (Bailey et al 2016, Nature). We also found that loss of CXCR2 was associated with a sw...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-6620 | biostudies-arrayexpress
UnknownReview of GPS collar deployments and performance on nonhuman primates.
Not available
S-EPMC8118416 | biostudies-literature
ProteomicsMetabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | MassIVE
MetabolomicsGNPS - Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | GNPS
GenomicsHomozygous loss-of-function variants in European cosmopolitan and isolate populations
Homozygous loss of function (HLOF) variants provide a valuable window on gene function in humans, as well as an inventory of the human genes that are not essential for survival and reproduction. All humans carry at least a few HLOF variants, but the exact number of inactivated genes that can be tole...
EGAS00001001606 | EGA
Genomicsena-DATASET-IGMM-28-09-2016-11:49:17:763-561 - samples
Exome sequencing of isolate populations and Generation Scotland
EGAD00001002715 | EGA
GenomicsQTL-DAC
Data Access Committee EGAC00001000063
EGAC00001000063 | EGA
GenomicsEGAS00001000165-sc-20150427 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001353 | EGA
GenomicsEGAS00001000902-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001351 | EGA
GenomicsEGAS00001000160-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001349 | EGA
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