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TranscriptomicsMicroRNA profiling of human breast cancer cell line MCF7 under conditions of hypoxia
Hypoxia results in the changes in expression of many genes, the majority of which are mediated via the transcriptional activity of the hypoxia inducible factor (HIF) complex. However, other mechanisms of gene regulation by hypoxia are likely and include control of mRNA stability, regulation of mRN...
ORGANISM(S): Homo sapiens 
2008-03-01 | E-MEXP-1111 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of early primary breast cancer to identify prognostic markers and associated pathways
Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-22216 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47534 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia [mRNA]
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47533 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia [miRNA]
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47532 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia (miRNA-Seq)
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47602 | biostudies-arrayexpress
TranscriptomicsIdentification of microRNAs association with Rheumatoid Arthritis Synovial Fibroblasts using the Human TNF Transgenic Mouse Model
OBJECTIVE: MicroRNAs (miRNAs, miRs), a class of small non-coding RNA molecules, are posttranscriptional regulators involved in a plethora of cellular functions and have been proposed as potential therapeutic targets in various diseases, including rheumatoid arthritis (RA). In this study, we sought t...
ORGANISM(S): Mus musculus 
2012-05-13 | E-GEOD-31667 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsTGF-beta/Smad2/3 signaling directly regulates several miRNAs in mouse ES Cells and early embryos
Purpose: We aimed to identify miRNAs which are induced by the Activin/Nodal effectors, P-Smad2/3, in order to further our understanding of how P-Smad2/3 controls downstream gene expression in mouse ES cells to regulate crucial biological processes. Methods: We used a previously developed Tetracyclin...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39994 | biostudies-arrayexpress
GenomicsChIP-seq
Genome wide analysis RNA polymerase II (RNA Pol II) and histone marker H3K4me3 in hypoxia and normoxia using ChIP-seq. Breast cancer cell line (MCF-7) is cultured in normoxic condition (21% O2) and hypoxic condition (0.5%O2) for 16 hours. Immunoprecipitation of RNA Pol II and H3K4me3.
ORGANISM(S): Homo sapiens 
2014-02-10 | E-MTAB-1995 | biostudies-arrayexpress
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