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ProteomicsCharacterisation of the gut microbiota metaproteome in patients affected by the Williams Beuren syndrome
Analyses were performed on stool samples collected from 41 patients affected by Williams Beuren syndrome (Wills, WBSs) to evaluate their gut microbiota metaproteome signatures by LFQ and LCA approaches in comparison to 45 healthy subjects (controls, CTRs, CTRLs)
ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091045 | MassIVE
TranscriptomicsRNAseq of young adult C. elegans animals fed on three different bacterial diets, E. coli OP50, B. subtilis PXN21 and a mixture of both
To uncover the host response pathways that are modified by a B. subtilis diet and that may provide the protective effect against α-synuclein aggregation, we performed comparative global transcriptomics analysis using next generation RNA sequencing (RNA-seq). We compared young adult animals fed on th...
ORGANISM(S): Caenorhabditis elegans 
2020-01-14 | E-MTAB-8164 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colon mucosa after cytotoxic insult in wild type and Apc-mutated rats: possible relation with resistance to apoptosis during carcinogenesis
Gene expression profiles of the colon mucosa of wild type and PIRC rats after 1,2-dimethylhydrazine (DMH)-treatment
ORGANISM(S): Rattus norvegicus 
2016-11-03 | E-MTAB-4910 | biostudies-arrayexpress
TranscriptomicsTRANSCRIPTOME ANALYSIS DURING THE METAMORPHOSIS OF THE ASCIDIAN CIONA INTESTINALIS
Tunicates, including ascidians, are recognized as the true “sister group” of vertebrates and are emerging as models to study the development and degeneration of central nervous system (CNS). Ascidian larvae have the typical chordate body plan that includes a dorsal neural tube. During their metamorp...
ORGANISM(S): Ciona intestinalis 
2024-08-31 | E-MTAB-13385 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colon mucosa in wt and Apc-mutated Pirc rat
We evaluated the gene expression profiles of Pirc rats (mutated for the APC gene) at one month of age, prior to the development of visible preneoplastic tumors or lesions. The analysis was performed on both female and male animals, comparing Pirc rats with wild type F344 rats of the same age.
ORGANISM(S): Rattus norvegicus 
2021-07-30 | E-MTAB-10016 | biostudies-arrayexpress
MetabolomicsTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan

PURPOSE: Validated biomarkers of food intake (BFIs) have recently been suggested as a useful tool to assess adherence to dietary guidelines or compliance in human dietary interventions. Although many new candidate biomarkers have emerged in the last decades for different foods fr...

2020-04-28 | MTBLS469 | MetaboLights
ProteomicsLabel-free quantitative data dependent (DDA) nano-LC-MS/MS proteomic profiling of mouse lymph harvested from mesenteric and cervical anatomical districts
To fully quantify differences in the lymph composition and associated dendritic cells antigenic load, from different anatomical districts and in physiological and pathological conditions, we collected the afferent lymph draining to the cervical and mesenteric lymph nodes in healthy mice. Most of th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-04-21 | MSV000094586 | MassIVE
TranscriptomicsMajor Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures
In this work we aimed to perform, for the first time in human clear cell renal cell carcinoma (ccRCC), a comprehensive and detailed study of endogenous LOX expression and functions. To overcome the difficulties and limitations due to tissue heterogeneity, we took advantage of a consolidated in vitro...
ORGANISM(S): Homo sapiens 
2016-06-06 | E-MTAB-4074 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human healthy volunteers and IBS patients
Micro-inflammation and gut dysfunction are features of diarrhea-irritable bowel syndrome (d-IBS) patients, although the underlying interacting molecular mechanisms remain mostly unknown. Therefore, we aimed to identify critical networks and signaling pathways active in chronic diarrhea-associated in...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14841 | biostudies-arrayexpress
TranscriptomicsTotal and cholera toxin B-tetramer specific T cells from Peyer's patches and mesenteric lymph nodes
T cells were separately isolated from MLN and PP from two naive mice, and T cells binding to a cholera toxin B subunit specific MHC II tetramer from mice orally immunized with cholera toxin 7 days or boosted 5 days with a second dose of cholera toxin. Cells were purified using flow cytometric cell s...
ORGANISM(S): Mus musculus 
2022-06-22 | E-MTAB-11805 | biostudies-arrayexpress
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