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TranscriptomicsKlf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane Beta1/Beta2-integrin expression
The Kruppel-like factor 5 (Klf5) regulates pluripotent stem cell self-renewal but its role in somatic stem cells is unknown. Klf5 deficient hematopoietic stem cells and progenitors (HSC/P) fail to engraft after transplantation. This HSC/P defect was associated with impaired bone marrow (BM) homing a...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-43806 | biostudies-arrayexpress
UnknownP2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis.
Not available
S-EPMC8959601 | biostudies-literature
UnknownAn inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.
Not available
S-EPMC5335359 | biostudies-literature
TranscriptomicsTranscription profiling of human cord blood cells transduced with Leukemia fusion-gene
MLL-AF9 expression in normal human umbilical cord blood CD34+ cells leads to long-term proliferation of a myeloid progenitor cell with leukemogenic potential. Expression of a Core Binding Factor leukemia fusion (AML1-ETO or CBFbeta-SMMHC) in human CD34+ cells results in self-renewal of primitive pro...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7011 | biostudies-arrayexpress
Unknownp190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
Not available
S-EPMC3919554 | biostudies-literature
UnknownIODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.
Not available
S-EPMC7067412 | biostudies-literature
UnknownMicroenvironment determines lineage fate in a human model of MLL-AF9 leukemia.
Not available
S-EPMC2486365 | biostudies-literature
UnknownInhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.
Not available
S-EPMC2809821 | biostudies-literature
UnknownCharacterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma.
Not available
S-EPMC9306459 | biostudies-literature
UnknownNF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.
Not available
S-EPMC7243727 | biostudies-literature
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