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MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
TranscriptomicsExpression data from human glioma cancer stem cell (CSC) specimens following knockdown of GREM1
CSCs differentially secrete the BMP antagonist Gremlin1 compared to non-stem glioma populations. Knockdown of Gremlin1 decreases CSC proliferation and tumorigenicity, establishing Gremlin1 as an essential effector for CSC maintenance. We used a microarray to determine the gene expression programs t...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-52846 | biostudies-arrayexpress
ProteomicsExosomes from GBM established cell lines (U87, U373) and GBM primary CSC
In this study, we investigated and compared the miRNA and protein content of the small EVs released by different human GBM established cell lines and by GBM primary CSC lines, to explore the role of EVs in their different tumor behavior and capacities.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-11 | MSV000088671 | MassIVE
ProteomicsCharacterization of the cholangiocarcinoma stem cells by proteomics
Comparison of global proteome between stem cells, differentiating stem cells, and parental cells of cholangiocarcinoma.
ORGANISM(S): Homo Sapiens (human) 
2024-02-08 | PXD039953 | JPOST Repository
TranscriptomicsMicroRNA expression profiling of Ewing sarcoma cancer stem cells
We have recently demonstrated that human paediatric mesenchymal stem cells can be reprogrammed toward a Ewing’s sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSC is shared by embryonic stem c...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-30513 | biostudies-arrayexpress
TranscriptomicsPNAs-A15 effects on non-small cell lung cancer cell line
Expression profile of parental wild type non-small cell lung cancer, NCI-H460, and cancer stem cell-rich (CSC-rich) populations treated with PNAs-A15 for 6 h. Results provide the information that PNAs-A15, a peptide nucleic acid of A-repeats length 15 bp, suppressed up-regulated A-repeats containing...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-79308 | biostudies-arrayexpress
ProteomicsHematopoietic stem cell derived conditioned media metabolomics
Metabolomic data of conditioned media derived from culturing hematopoietic stem cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-14 | MSV000097113 | MassIVE
TranscriptomicsThe side population of human pancreatic cancer expresses cancer stem cell-associated genes
Purpose: To explore the side population (SP) in pancreatic ductal adenocarcinoma (PDAC) for its gene expression profile and its association to cancer stem cells (CSC) and to evaluate the value of genes from its gene signature on patient survival. Experimental design: Side and main population (MP) c...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-42404 | biostudies-arrayexpress
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