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TranscriptomicsExpression data from Arabidopsis thaliana root protoplast
BACKGROUND:Dynamic transcriptional regulation is critical for an organism's response to environmental signals and yet remains elusive to capture. Such transcriptional regulation is mediated by master transcription factors (TF) that control large gene regulatory networks. Recently, we described a dyn...
ORGANISM(S): Arabidopsis thaliana 
2016-02-08 | E-GEOD-69389 | biostudies-arrayexpress
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

<...
2025-03-28 | MTBLS10098 | MetaboLights
TranscriptomicsThe Populus transciptome in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence
Over recent decades the progression of natural autumnal senescence has been increasingly delayed across wide areas of the Northern Hemisphere and is thought to be caused by rising temperature. Recently this delay has been shown to be partly attributable to rising atmospheric carbon dioxide concentr...
ORGANISM(S): Populus x canadensis 
2010-01-31 | E-GEOD-15874 | biostudies-arrayexpress
GenomicsEpigenomic changes associated with TGF-beta induced EMT in MDCK cells.
Our group is interested in epithelial-to-mesenchymal transition (EMT), in particular, TGF-beta induced EMT. TGF-beta signalling has been shown to be an important factor in the induction of EMT and it has been demonstrated that adding TGF-beta to epithelial cells in culture is a convenient way to stu...
ORGANISM(S): Canis lupus familiaris 
2017-10-23 | E-MTAB-5637 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis cells cultures undergoing transdifferentiation
The formation of vascular tissue occurs when cellulose, hemicellulose, lignin and other wall components are deposited within the primary cell wall. These secondary thickened cells then undergo programmed cell death producing a network of empty cells with which water and ions can be transported thro...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6148 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis iae1 and iae2 phenotypes
The mutants iae1 and iae2 have been mapped to two distinct loci on chromosome 2. With the aid of the GetCID service, we believe iae1 has been localised to a relatively small region (~100kb); while mapping has restricted iae2 to a small interval (~50kb) with a very limited number of candidate genes....
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6175 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis reveals organ regeneration in plants is independent of stem cell niche activity
A critical step in regeneration is recreating the cellular identities and patterns of lost organs long after embryogenesis is complete. In plants, perpetual (indeterminate) organ growth occurs in apical stem cell niches, which have been shown to re-establish quickly when damaged or removed (1,2). He...
ORGANISM(S): Arabidopsis thaliana 
2008-11-13 | E-GEOD-9996 | biostudies-arrayexpress
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
GenomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress
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