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UnknownStand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Not available
S-EPMC3986383 | biostudies-literature
TranscriptomicsAkt-Induced Mitochondrial Dysfunction in the Heart
Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction in pathological LVH. Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation ...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63848 | biostudies-arrayexpress
MetabolomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1223 | MetaboLights
ProteomicsSARS-CoV-2 phosphoproteomics - ACE2-A549 and Vero
Multiple coronavirus have emerged independently in the past 20 years and caused lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be vaccinated. Understanding the common host factors ne...
ORGANISM(S): Homo sapiens (Human) Chlorocebus sabaeus 
2023-03-11 | PXD033015 | Pride
Covid-19 Sars-cov-2 Phosphoproteomics 
UnknownLysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.
Not available
S-EPMC12308713 | biostudies-literature
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-40191 | biostudies-arrayexpress
ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
UnknownTTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Not available
S-EPMC3739326 | biostudies-literature
UnknownProline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.
Not available
S-EPMC7599336 | biostudies-literature
UnknownPIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer.
Not available
S-EPMC6757060 | biostudies-literature
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