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UnknownStand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.

Purpose

Buparlisib, an oral reversible inhibitor of all class I phosphoinositide-3-kinases, has shown antitumoral activity against estrogen receptor (ER)-positive breast cancer cell lines and xenografts, alone and with endocrine therapy. This phase Ib study evaluated buparlisib plus letrozol...
S-EPMC3986383 | biostudies-literature
ProteomicsSARS-CoV-2 phosphoproteomics - ACE2-A549 and Vero
Multiple coronavirus have emerged independently in the past 20 years and caused lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be vaccinated. Understanding the common host factors ne...
ORGANISM(S): Homo sapiens (Human) Chlorocebus sabaeus 
2023-03-11 | PXD033015 | Pride
Covid-19 Sars-cov-2 Phosphoproteomics 
ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
ProteomicsThe ribotoxic stress response drives UV-mediated cell death.
Supporting raw MS data for paper (doi: 10.1016/j.cell.2024.05.018) by Sinha N.K. et al, titled "The ribotoxic stress response drives UV-mediated cell death". Index of MS files and labels Table S1 - HaCaT Timecourse. 1-1 - Proteome (AO3604-3627 | Unimod:35; 2016; 4 | 126 -UT_01; 127n - UT_02; 12...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-25 | MSV000092521 | MassIVE
ProteomicsNAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Supporting raw MS data for paper (DOI:10.1083/jcb.202303082) by Paul S. et al., titled "NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis". Index of MS supporting files uploaded: - Related to Figure 6A;S4A (AO3556-AO3579: whole proteome (Unimod: 35; 2016; 4)). -...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-01 | MSV000093220 | MassIVE
UnknownPost-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
mTORC1 is a signal integrator and master regulator of cellular anabolic processes linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins. mTORC1-activated S6K1 phosphorylates SRPK2 at Ser494, which primes S...
S-EPMC5920692 | biostudies-literature
ProteomicsMultiplexed proteomics of a cellular transition from G0 to cell cycle in response to IL-3 activation
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation of these metabolic changes have not been properly e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-21 | MSV000081179 | MassIVE
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-40191 | biostudies-arrayexpress
ProteomicsAge-induced methylmalonic acid accumulation promotes cancer aggressiveness and metastatic disease
TMT protein abundance profiling of human serum from 30 young and 30 older adults.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-18 | MSV000084974 | MassIVE
ProteomicsMotif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity
Plant cell surface pattern recognition receptors (PRRs) perceive non- or altered-self elicitors to induce immune responses. PRRs relay information across the plasma membrane and trigger downstream signaling via receptor-like cytoplasmic kinases (RLCKs) such as BOTRYTIS-INDUCED KINASE 1 (BIK1). BIK1 ...
ORGANISM(S): Arabidopsis Thaliana 
PXD066643 | panorama
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