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GenomicsGenome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome.
Previous studies of E2F family members have suggested that protein-protein interactions may be the mechanism by which E2Fs are recruited to specific genomic regions. We have addressed this hypothesis on a genome-wide scale using ChIP-seq analysis of MCF7 cell lines that express tagged wildtype and m...
ORGANISM(S): Homo sapiens 
2011-04-04 | E-GEOD-28286 | biostudies-arrayexpress
GenomicsL3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-Seq data].
Human MBT domain-containing protein L3MBTL2 was found to be an integral component of a protein complex that we termed Polycomb Repressive Complex 1-like 3 (PRC1L3) given the presence of the PcG proteins RING1, RING2 and PCGF6. L3MBTL2 binds chromatin in a histone modification-independent manner and ...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28162 | biostudies-arrayexpress
TranscriptomicsL3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-chip data].
Human  MBT  domain‐containing  protein  L3MBTL2  was  found  to  be  an  integral  component  of   a  protein  complex  that  we  termed  Polycomb  Repressive  Complex  1‐like  3  (PRC1L3)  given  the  presence   of  the  PcG  proteins  RING1,  RING2  and  PCGF6.  L3MBTL2  binds  chromatin  in  a  h...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28161 | biostudies-arrayexpress
TranscriptomicsGene exrpression profiling of childhood adrenocortical tumors
Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermin...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75415 | biostudies-arrayexpress
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