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TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsRNA-seq Experiments from Saccharomyces cerevisiae
RNA-seq Experiments from Calorie Restricted and Non-Restricted WT Yeast We used RNA-seq to study transcriptome changes under Calorie Restricted and Non-restricted Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-15 | E-GEOD-53720 | biostudies-arrayexpress
TranscriptomicsGene expression data from obatoclax-treated SEM-K2 and RS4:11 cell lines
Effects of the pan-anti-apoptotic BCL-2 family small molecule inhibitor, obatoclax mesylate (GeminX Pharmaceuticals), on gene expression were evaluated by microarray analysis in order to gain insights into the killing mechanism by this compound in two human MLL-AF4 cell lines. The results of the gen...
ORGANISM(S): Homo sapiens 
2012-04-23 | E-GEOD-36149 | biostudies-arrayexpress
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