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TranscriptomicsTranscription profiling of yeast mutant strains vs WT: YIA29 (mdl1::HIS3); YIA30 (yme1::KAN); YIA31 (mdl1::HIS3 yme1::KAN);
All yeast strains were in the genetic background W303-1A (MATa leu2-3,112 trp1-1 ura3-1 can1-100 ade2-1 his3-11,15). Gene expression profiles of the following mutant strains were compared with WT: YIA29 (mdl1::HIS3); YIA30 (yme1::KAN); YIA31 (mdl1::HIS3 yme1::KAN); 2 independent RNA preparations per...
ORGANISM(S): Saccharomyces cerevisiae 
2005-12-31 | E-EMBL-5 | biostudies-arrayexpress
TranscriptomicsExon array analysis in primary human fibroblasts
Exon usage analysis in in vitro cultured fibroblast cells. To assay the genome-wide splicing changes during cellular senescence, we performed splicing analysis on young and old normal fibroblasts, and in fibroblasts +/- tert (telomerase protein subunit Tert immortalized). We analyzed primary fibrobl...
ORGANISM(S): Homo sapiens 
2011-06-17 | E-GEOD-28863 | biostudies-arrayexpress
ProteomicsPotential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Antibiotic resistance is increasingly becoming a serious challenge to public health. The regulation of metabolism by post-translational modifications (PTMs) has been widely studied; however, the comprehensive mechanism underlying the regulation of acetylation in bacterial resistance against antibiot...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-10-14 | PXD030283 | Pride
Post-translational modification  escherichia coli  acetylation  pykf  antibiotic resistance 
UnknownSpecific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells
Not available
S-EPMC9519352 | biostudies-literature
TranscriptomicsExpression of 50-500nt ncRNAs in silkworm Bombyx mori during two developmental transitions
We have performed the first systematic identification and analysis of intermediate size ncRNAs (50-500 nt) in the silkworm genome. We identified 194 novel ncRNAs, the expression profiles of them during the transitions from the egg to the first instar larva and from the fifth instar larva to the pupa...
ORGANISM(S): Bombyx mori 
2010-12-22 | E-GEOD-22912 | biostudies-arrayexpress
GenomicsCorrelated alterations in genome organization, histone methylation, and DNA-lamina interactions in Hutchinson-Gilford progeria syndrome (Hi-C)
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA. This mutation activates a cryptic splice donor site in exon 11, and leads to an in-frame deletion within the prelamin A mRNA and the production of ...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-41763 | biostudies-arrayexpress
UnknownA real-time spike classification method based on dynamic time warping for extracellular enteric neural recording with large waveform variability.
Not available
S-EPMC4749467 | biostudies-literature
UnknownDesign, Synthesis, and Antibacterial Evaluation of Novel Ocotillol Derivatives and Their Synergistic Effects with Conventional Antibiotics.
Not available
S-EPMC8512374 | biostudies-literature
GenomicsCorrelated alterations in genome organization, histone methylation, and DNA-lamina interactions in Hutchinson-Gilford progeria syndrome (ChIP-seq)
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA. This mutation activates a cryptic splice donor site in exon 11, and leads to an in-frame deletion within the prelamin A mRNA and the production of ...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-41757 | biostudies-arrayexpress
TranscriptomicsS. coelicolor LY2517 R5- medium time course study (Culture # 1)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this study,...
ORGANISM(S): Streptomyces coelicolor 
2012-12-19 | E-GEOD-21809 | biostudies-arrayexpress
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