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TranscriptomicsExpression data from human 3D skin models in response to IL-31 treatment
Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalance, is closely associated with skin barrier defects. A cytokine related to disease severity and inhibition of keratinocyte differentiation is IL-31. To identify its molecular targets, IL-31-dependent gene expression was d...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-76880 | biostudies-arrayexpress
GenomicsChIP-seq of H3K4me3 and H3K27ac of dermal fibroblasts
Dermal fibroblasts from human, rhesus macaque, mouse and rat with and without dsRNA (poly I:C) stimulation (1ug/mL for 4 hours).
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable among responding cells, as well as to rapidl...
ORGANISM(S): Mus musculus 
2018-07-06 | E-MTAB-5918 | biostudies-arrayexpress
TranscriptomicsLong-term exposure to cold plasma-generated ROS –an in vitro model for redox-related diseases of the skin
Oxidative stress illustrates an imbalance between radical formation and removal. Frequent redox stress is critically involved in a variety of human pathologies including cancer, psoriasis, and chronic wounds. However, reactive species pursue a dual role being involved in signaling on the one hand an...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-74876 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of primary adult human skin cells that express stage-specific embryonic antigen 3 (SSEA-3)
Primary human skin cells were gated based on expression of stage-specific embryonic antigen 3 (SSEA3) with the high SSEA3 expressing cells (top 10%, categorized as SSEA3-positive or SSEA3-high) and negative SSEA3 expressing cells (bottom 10%, categorized as SSEA3-negative) purified into two differen...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33066 | biostudies-arrayexpress
UnknownSARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1.
Not available
S-EPMC10444022 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq of CD4+ Treg and Tmem cells from different tissues in mouse and human
Non-lymphoid tissues (NLTs) harbour a pool of adaptive immune cells distinct from their counterparts in lymphoid tissues, and their development and phenotype remains largely unexplored. We used scRNA-seq to survey CD4+ T regulatory (Treg) and memory T (Tmem) cells in spleen, lymph nodes, skin and co...
ORGANISM(S): Mus musculus 
2018-12-31 | E-MTAB-6072 | biostudies-arrayexpress
TranscriptomicsProspective surface marker-based isolation and expansion of fetal endothelial colony-forming cells from human term placenta.
The term placenta is a highly vascularized tissue and is usually discarded upon birth. Our objective was to isolate clinically relevant quantities of fetal endothelial colony-forming cells (ECFCs) from human term placenta and to compare them to the well-established donor-matched umbilical cord blood...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-MTAB-3277 | biostudies-arrayexpress
TranscriptomicsArabidopsis thaliana response to ozone
Comparison of Arabidopsis seedlings exposed to 500 ppb ozone with air treated control plants.
ORGANISM(S): Arabidopsis thaliana 
2005-05-25 | E-MEXP-342 | biostudies-arrayexpress
TranscriptomicsClarion GO screen assay to assess gene expression responses of human mature adipocytes under control and IL-1B induced conditions in response to herbal extracts of Sage (S. offinicalis) and Chamomile (C. nobile).
Chronic inflammation plays a critical role in the initiation and development of various human illnesses. The use of steroidal anti-inflammatory drugs (SAIDs) or non-steroidal anti-inflammatory drugs (NSAIDs) is now much more frequent and presents a number of unwanted side effects. For example long-...
ORGANISM(S): Homo sapiens 
2020-10-05 | E-MTAB-9609 | biostudies-arrayexpress
TranscriptomicsFC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the p...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-40464 | biostudies-arrayexpress
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