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ProteomicsThe atrial and ventricular myocardial proteome of end-stage lamin heart disease
Background: Lamins A/C (encoded by the LMNA gene) can lead to dilated cardiomyopathy (DCM). Objectives: This study sought to undertake proteomic analysis of myocardial tissue to explore the postgenomic phenotype of end-stage lamin heart disease. Methods: Consecutive patients with end-stage lamin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040488 | Pride
Lamin Human Heart 
ProteomicsA new multiplexed plasma biomarker panel developed using targeted proteomics and machine learning has diagnostic and prognostic potential in children with hypertrophic cardiomyopathy
Background Hypertrophic cardiomyopathy (HCM) is defined clinically by pathological left ventricular hypertrophy (LVH). We have previously developed a plasma proteomics biomarker panel that correlates with clinical markers of disease severity and sudden cardiac death (SCD) risk in adult patients with...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045304 | Pride
Childhood-onset hcm proteomics 
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