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TranscriptomicsTenascin-C shapes TRAIL control over tumor immunity
TRAIL cytotoxicity is exploited as anti-cancer therapy since many years, however incomplete knowledge is generating many obstacles. Here, we address whether the highly abundant extracellular matrix molecule tenascin-C (TNC) orchestrating an immune suppressive tumor microenvironment and binding TRAIL...
ORGANISM(S): Mus musculus 
2024-05-30 | E-MTAB-14089 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of NT193 cells with an epithelial (E) and mesenchymal (M) phenotype
Cells have been collected by limited dilution and mRNA from 3 consequtive passages of cells cultured in Dulbecco’s modified Eagle’s medium (DMEM Dutscher L0104-500) containing 4.5 g/L glucose, L-glutamine, sodium pyruvate supplemented with 10% of inactivated fetal bovine serum (FBS, Dutscher S1510-5...
ORGANISM(S): Mus musculus 
2024-07-13 | E-MTAB-14200 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of Fusarium graminearum to plant cell wall substrates
We report a complete transcriptomic study of Fusarium graminearum in response to glucose, cellulose, xylan and cell wall fragments with a whole genome microarray from febit. Fusarium graminearum was cultured at 25 °C on minimal M3 medium with glucose, birch wood xylan, carboxy methyl cellulose or ho...
ORGANISM(S): Gibberella zeae 
2011-06-16 | E-GEOD-29973 | biostudies-arrayexpress
TranscriptomicsLymphopenia-induced T cell exhaustion in STING gain-of-function mouse model
STING gain-of-function (GOF) mutations lead to T cell lymphopenia, in the context of severe combined immunodeficiency (SCID) for STING GOF V154M mice. This T cell lymphopenia, which is of central origin, has been described as type I IFN independent and associated with dysfunctions of the rare mature...
ORGANISM(S): Mus musculus 
2024-01-07 | E-MTAB-13658 | biostudies-arrayexpress
TranscriptomicsTargeting the MAtrix REgulating MOtif, MAREMO, abolishes hallmarks of cancer
Tumor targeted therapies have been largely inefficient due to lack of concomitant effects on the tumor microenvironment (TME). We investigated the MAtrix REgulating MOtif (MAREMO) mimicking peptide MP5, that inhibits the pro-tumorigenic extracellular matrix (ECM) molecule tenascin-C, using immunocom...
ORGANISM(S): Mus musculus 
2024-01-20 | E-MTAB-13677 | biostudies-arrayexpress
TranscriptomicsReticular fibroblasts counteract radiotherapy-induced head and neck tumor regression through Tenascin-C
Head and neck squamous cell carcinoma (HNSCC) patients have a very short survival. To improve patient survival, there is an emerging need for a better understanding of the obstacles of ionizing irradiation (IR), besides surgery, currently the best treatment option for HNSCC. A confounding factor is ...
ORGANISM(S): Mus musculus 
2025-02-14 | E-MTAB-14801 | biostudies-arrayexpress
TranscriptomicsAnalysis of RNA-sequence reads: Variant calling in epithelial cancer cells isolated from C57BL6 mouse
Chemically-induced tongue cancer cells were extracted and isolated from C57BL6 mice. They were then grafted twice into the neck of C57BL6 mice in order to increase their tumorigenic capacities before being isolated and cultured again until passage 9. RNA was extracted from these cells for transcript...
ORGANISM(S): Mus musculus 
2021-06-28 | E-MTAB-10614 | biostudies-arrayexpress
TranscriptomicsPlatelets favor the outgrowth of established metastases
Despite abundant evidence demonstrating that platelets foster metastasis, anti- platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subjected syngene...
ORGANISM(S): Mus musculus 
2024-03-10 | E-MTAB-13864 | biostudies-arrayexpress
TranscriptomicsCell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells
Metastases arise from a multi-step process during which tumor cells change their mechanics in response to microenvironmental cues. While such mechanical adaptability could influence metastatic success, how tumor cell mechanics directly impacts intravascular behavior of circulating tumor cells (CTCs)...
ORGANISM(S): Mus musculus 
2024-11-24 | E-MTAB-14571 | biostudies-arrayexpress
TranscriptomicsRNAseq of peripheral blood mononuclear cells from related Hyperimmunoglobinemia D patients presenting with different phenotypes
The aim of this study was to understand why two siblings carrying both the same homozygous causal mutation for the auto-inflammatory disease hyper IgD syndrome show opposite phenotypes, i.e. the first being asymptomatic, the second presenting all classical characteristics of the disease.
ORGANISM(S): Homo sapiens 
2018-03-23 | E-MTAB-6563 | biostudies-arrayexpress
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