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ProteomicsCampylobacter jejuni MOMP carbene footprinting
Using carbene footprinting, we map the MOMP-QPLEX interaction and show by complementary in silico docking that QPLEX enters the porin channel through interactions at the extracellular face, translocates down the channel through a dipole transverse electric field towards the opposite end and is relea...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168-PO 
2022-09-26 | PXD035978 | Pride
Carbene footprinting Campylobacter jejuni Lc-ms/ms 
ProteomicsMapping the Interaction between Eukaryotic Initiation Factor 4A (eIF4A) and the Inhibitor Hippuristanol Using Carbene Footprinting and Mass Spectrometry
Protein-ligand interactions are central to protein activity and cell functionality. Improved knowledge of these relationships greatly benefits our understanding of key biological processes and aids in rational drug design towards the treatment of clinically relevant diseases. Carbene footprinting is...
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD025105 | Pride
Protein footprinting Mapping ligand binding Carbene labelling 
ProteomicsMapping the Binding Interactions Between human Gasdermin D and human Caspase-1 Using Carbene Footprinting
Carbene footprinting is a recently developed mass spectrometry-based chemical labeling technique that probes protein interactions and conformation. Here, we use the methodology to investigate binding interactions between the protease human Caspase-1 (C285A) and full-length human Gasdermin D (hGSDMD)...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD040212 | Pride
Gsdmd Footprinting Lc-ms Interaction Caspase-1 
ProteomicsComplete integration of carbene-transfer chemistry into biosynthesis
Biosynthesis is an environmentally friendly and renewable way to synthesize a broad range of natural and some new-to-nature products; however, it lacks many of the reactions and flexibility of synthetic chemistry, an example being carbene mediated reactions. While it was recently shown that these re...
ORGANISM(S): Streptomyces albus J1074 
2023-05-03 | PXD037509 | Pride
Streptomyces albus P450 Biosynthesis Carbene meidated reaction 
ProteomicsCarbene footprinting reveals binding interfaces of a multimeric membrane spanning protein
Mapping the interaction sites between membrane spanning proteins is a key challenge in structural biology. Here we develop and apply carbene footprinting technology to identify the interfacial sites of a trimeric membrane protein. We show how the footprinting probe is effectively incorporated into d...
ORGANISM(S): Escherichia coli 
2017-09-29 | PXD007207 | Pride
Footprinting Protein Carbene Lc-ms Membrane 
ProteomicsCarbene Footprinting Accurately Maps Binding Sites in Protein-Ligand and Protein-Protein Interactions
Specific interactions between proteins and their binding partners are fundamental to life processes. Differential protein footprinting using a new and efficient, photo-activated aryltrifluromethylcarbene probe together with mass spectrometry has been employed to identify protein-ligand and protein-p...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2016-12-19 | PXD004971 | Pride
Lysozyme Carbene footprinting Usp5 Covalent labelling 
UnknownChemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase.
Not available
S-EPMC6291643 | biostudies-literature
UnknownGold(i)-catalyzed cycloisomerization of vinylidenecyclopropane-enes via carbene or non-carbene processes.
Not available
S-EPMC5949847 | biostudies-literature
UnknownCatalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase.
Not available
S-EPMC6048479 | biostudies-literature
UnknownCarbene Routes to Cyclopropatetrahedrane.
Not available
S-EPMC9764353 | biostudies-literature
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