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ProteomicsMapping the Interaction between Eukaryotic Initiation Factor 4A (eIF4A) and the Inhibitor Hippuristanol Using Carbene Footprinting and Mass Spectrometry
Protein-ligand interactions are central to protein activity and cell functionality. Improved knowledge of these relationships greatly benefits our understanding of key biological processes and aids in rational drug design towards the treatment of clinically relevant diseases. Carbene footprinting is...
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD025105 | Pride
Protein footprinting Mapping ligand binding Carbene labelling 
ProteomicsCarbene footprinting reveals binding interfaces of a multimeric membrane spanning protein
Mapping the interaction sites between membrane spanning proteins is a key challenge in structural biology. Here we develop and apply carbene footprinting technology to identify the interfacial sites of a trimeric membrane protein. We show how the footprinting probe is effectively incorporated into d...
ORGANISM(S): Escherichia coli 
2017-09-29 | PXD007207 | Pride
Footprinting Protein Carbene Lc-ms Membrane 
ProteomicsCarbene Footprinting Accurately Maps Binding Sites in Protein-Ligand and Protein-Protein Interactions
Specific interactions between proteins and their binding partners are fundamental to life processes. Differential protein footprinting using a new and efficient, photo-activated aryltrifluromethylcarbene probe together with mass spectrometry has been employed to identify protein-ligand and protein-p...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2016-12-19 | PXD004971 | Pride
Lysozyme Carbene footprinting Usp5 Covalent labelling 
UnknownTarget Agnostic Photoaffinity Labelling by Sulfonylhydrazones.
Not available
S-EPMC12015381 | biostudies-literature
UnknownIridium-Catalysed ortho-Directed Deuterium Labelling of Aromatic Esters--An Experimental and Theoretical Study on Directing Group Chemoselectivity.
Not available
S-EPMC6332247 | biostudies-literature
UnknownCarbene-catalyzed chirality-controlled site-selective acylation of saccharides.
Not available
S-EPMC11697312 | biostudies-literature
UnknownA combined experimental and computational study reveals a crossover between conventional cross-coupling and carbene insertion pathways in a Pd catalyzed C(sp<sup>2</sup>)-H insertion.
Not available
S-EPMC11915135 | biostudies-literature
Unknown1,2-N-migration in a gold-catalysed synthesis of functionalised indenes by the 1,1-carboalkoxylation of ynamides.
Not available
S-EPMC4204129 | biostudies-literature
UnknownFinding Furfural Hydrogenation Catalysts via Predictive Modelling.
Not available
S-EPMC3501696 | biostudies-literature
Unknown[(18)F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging.
Not available
S-EPMC5457534 | biostudies-literature
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