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TranscriptomicsExpression changes in MEL cells upon differentiation and Ldb1 knockdown
Carbonic anhydrase 1 (Car1), an early specific marker of the erythroid differentiation, has been used to distinguish fetal and adult erythroid cells since its production closely follows the γ- to β-globin transition, but the molecular mechanism underlying transcriptional regulation of Car1 is unclea...
ORGANISM(S): Mus musculus 
2012-12-11 | E-GEOD-42839 | biostudies-arrayexpress
Transcriptomicscarbonic anhydrase (1 or 2) simple or double mutants-Comparative transcriptome analysis between carbonic anhydrase mutants and wild type Arabidopsis
cea05-01_carbonic-anhydrase - carbonic anhydrase (1 or 2) simple or double mutants - Identification of genes differentially expressed in leaves of single CA1 and CA2 T-DNA insertional mutants and in the corresponding double mutant vs wild type - CA1 (At3g01500) and CA2 (At5g14740) T-DNA insertional ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-25 | E-GEOD-36625 | biostudies-arrayexpress
TranscriptomicsThe carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence
The purpose of this study was to examine how ethoxzolamide modulates gene M. tuberculosis gene expression at acidic pH. We observed that ethoxzolamide downregulates genes of the PhoPR regulon. Mtb strain CDC1551 was grown at 37C in T-25 vented, standing tissue culture flasks in 8 ml of buffered 7H9 ...
ORGANISM(S): Mycobacterium tuberculosis 
2015-05-20 | E-GEOD-63917 | biostudies-arrayexpress
Transcriptomicscarbonic anhydrase (1 or 2) simple or double mutants-Comparative transcriptome analysis between carbonic anhydrase mutants and wild type Arabidopsis
cea05-01_carbonic-anhydrase - carbonic anhydrase (1 or 2) simple or double mutants - Identification of genes differentially expressed in leaves of single CA1 and CA2 T-DNA insertional mutants and in the corresponding double mutant vs wild type - CA1 (At3g01500) and CA2 (At5g14740) T-DNA insertional ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-25 | GSE36625 | GEO
TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of Oryza sativa, ssp. japonica, cv. Kitaake leaves from plants lacking carbonic anhydrase in the chloroplast
The aim of this experiment was to assess the impact on the transcriptome of relocalisaiton of carbonic anhydrase activity from the chloroplast to the cytosol in Oryza sativa, ssp. japonica, cv. Kitaake. Four genome edited lines and one wil-type control line were analysed.
ORGANISM(S): Oryza sativa 
2024-06-10 | E-MTAB-14111 | biostudies-arrayexpress
TranscriptomicsCarbonic anhydrase VIII regulates glucose-induced insulin secretion and hepatic glucose production via IP3R1-mediated Ca2+ release
Intracellular Ca2+ dynamics represent a key mechanism in glucose-induced insulin secretion (GIIS) and hepatic glucose production (HGP). In this study, we demonstrated that Car8wdl mice, a global carbonic anhydrase VIII (CA8)-deficient model, had increased GIIS and moderate HGP elevation in vivo and ...
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-15682 | biostudies-arrayexpress
TranscriptomicsCharacterization of the transcriptional response to hypoxia in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxic or normoxic conditions
To interrogate the hypoxia response pathways affected by the depletion of CAIX in BC cells, we performed gene expression profiling using SurePrint G3 Human Gene Expression 60K microarrays in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxi...
ORGANISM(S): Homo sapiens 
2018-01-01 | E-MTAB-5512 | biostudies-arrayexpress
GenomicsAlveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.
Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.
PRJNA1267136 | ENA
TranscriptomicsZinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii
Zinc is an essential nutrient because of its role in catalysis and in stabilizing protein structure, but excess zinc can also be deleterious. Four nutritional zinc states have been identified in the alga Chlamydomonas reinhardtii: zinc toxic, zinc replete, zinc deficient and zinc limited. Growth is ...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-05-03 | E-GEOD-41096 | biostudies-arrayexpress
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